摘要
目的探讨高血压合并颈动脉粥样硬化患者脉压(PP)与结缔组织生长因子(CTGF)的关系。方法对我院2010年8月—2011年12月收治的136例高血压患者,行彩超检查其颈动脉粥样硬化程度,分为正常组和颈动脉斑块组,并实施24h动态血压监测,计算出平均PP。同时采用逆转录聚合酶链式反应(RT-PCR)法检测患者动脉血中CTGF的表达水平。结果颈动脉斑块组PP较正常组有增高,且CTGF也处于高表达水平,差异有统计学意义(P<0.05)。结论高血压合并颈动脉粥样硬化患者脉压与结缔组织生长因子有密切的联系,在一定程度上高水平的CTGF导致了高血压合并颈动脉粥样硬化患者脉压的变化。
Objective To investigate the pulse pressure in patients with hypertension complicated with carotid athero- sclerosis （PP） and connective tissue growth factor （CTGF） relationship. Methods In our hospital from 2010August to 2011 December, 136 eases of patients with hypertension, line color Doppler ultrasound examination of the carotid atherosclerosis, were divided into normal group and carotid plaque group, and the implementation ot24h ambulatory blood pressure monitoring, calculate the average PP. At the same time using reverse transeriptase polymerase chain reaction （ RT - PCR） method for the de- tection of＇arterial blood in patients with the expression level of CTGF. Results The carotid artery plaque group had significantly higher PP than normal group, and CTGF at high expression levels （P 〈 0. 05）. Conclusion The pulse pressure in patients of hypertension with carotid artery atherosclerosis with connective tissue growth factor are closely linked, to a certain extent, high levels of connective tissue growth factor in hypertension patients with carotid arterial atheresclerosis pulse pressure variation.
出处
《临床合理用药杂志》
2012年第21期1-2,共2页
Chinese Journal of Clinical Rational Drug Use
基金
佛山市医学类科技攻关项目(201008224)
关键词
高血压
颈动脉粥样硬化
脉压
结缔组织生长因子
Hypertension
Carotid atherosclerosis
Pulse pressure
Connective tissue growth factor
