期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血清sRAGE检测对妊娠高血压综合征的意义 被引量：6

在线阅读 下载PDF
导出
摘要 目的检测先兆子痫患者血清可溶性晚期糖基化终末产物受体(sRAGE)的水平,并探讨其与临床资料及血清生化指标的相关性。方法观察组为重度妊高征(先兆子痫)患者20例,对照组为同期收治的正常晚期妊娠患者20例,比较两组年龄、SBP、DBP、分娩时妊娠周数、孕妇初始及分娩时体质量、新生儿出生体质量、血清肌酐、尿酸、TC、TG、LDL-C、HDL-C、ALT、AST水平的差异。硫代巴比妥酸法测定血清丙二醛(MDA)水平。采用ELISA试剂盒检测血清sRAGE水平。结果与对照组比较,观察组SBP、DBP、血肌酐、尿酸、LDL-C、MDA水平明显升高(P均<0.01),血清TC、TG、ALT、sRAGE水平亦有升高(P均<0.05),分娩时间和新生儿出生体质量降低(P均<0.01);血清sRAGE水平与血清肌酐、尿酸、HDL-C、ALT水平呈正相关(P<0.05),与MDA水平呈负相关(P<0.01)。结论在先兆子痫患者,sRAGE水平升高,可能成为监测妊高征病情及疾病对治疗反应的敏感性较高的生物学标记。
作者 宋春红 赵松 梁珊 王莉
机构地区 石家庄市第四医院 河北医科大学
出处 《山东医药》 CAS 2012年第24期88-89,共2页 Shandong Medical Journal
关键词 妊娠高血压综合征 可溶性晚期糖基化终末产物受体 丙二醛
分类号 R714.24 [医药卫生—妇产科学]
  • 相关文献

参考文献8

  • 1乐杰.妇产科学[M]5版[M].北京:人民卫生出版社,2001.129.
  • 2Yamagishi S, Matstti T. Soluble form of a receptor for advanced giy- cation end products (sRAGE) as a biomarker [ J ]. Front Biosci (Elite Ed), 2010,2:1184-1195.
  • 3Germanov~t A, Koucky M, H6jek Z, et al. Soluble receptor for ad- vanced glycation end products in physiological and pathological preg- nancy [ J ]. Clin Biochem, 2010,43 (4-5) :442-446.
  • 4Nakamura K, Yamagishi S, Adachi H, et al. Serum levels of sRAGE, the soluble form of receptor for advanced glycation end products, are associated with inflammatory markers in patients with type 2 diabetes [J]. Mol Med, 2007,13(3-4):185-189.
  • 5Tan KCB, Shiu SWM, Chow WS, et al. Association between serum levels of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes [ J]. Diabetologia, 2006,49( 11 ) :2756-2762.
  • 6Kalousovs M, Hodkova M, Kazderova M, et al. Soluble receptor for advanced glycation end products in patients with decreased renal function [J]. Am J Kidney Dis, 2006,47(3) :406-411.
  • 7Suliman ME, Heimbtirger O, Baray P, et al. Plasma peritosidine is associated with inflammation and malnutrition in end-stage renal disease patients starting on dialysis therapy [ J]. J Am Soc Nephrol, 2003,14(6) :1614-1622.
  • 8Semba RD, Ferrucci L, Fink JC, et al. Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling women [J]. Am J Kidney Dis, 2009, 53(1) :51-58.

共引文献201

同被引文献55

  • 1舒敏.正常妊娠与妊娠高血压疾病14项生化指标变化的探讨[J].医学信息（医学与计算机应用）,2014,0(22):419-419. 被引量：1
  • 2Zongo D, Ribereau- Gayon R, Masson F, et al. S100-B protein as a screening tool for the early assessment of minor head injury [ J]. Ann Emerg Med, 2012, 59(3 ) : 209 - 218.
  • 3Pelinka L, Harada N, Szalay L, et al. Release of S100b differs during ischemia and reperfusion of the liver, the gut and the kid- ney in rats[J]. Shock, 2004, 21(1): 72-76.
  • 4Capone AC, Safar P, Stezoski W, et al. Improved outcome with fluid restriction in treatment of uncontrolled hemorrhagic shock [J]. J Am Coll Surg, 1995, 180(1): 49 -56.
  • 5Pelinka LE, Bahrami S, Szalay L, et al. Hemorrhagic shock in- duces an S100B increase associated with shock severity [ J ]. Shock, 2003, 19(5) : 422 -426.
  • 6Donato R, Sorci G, Riuzzi F, et al. S100bs double life: intracel- lular regulator and extracellular signal[J]. Biochim Biophys Acta, 2009, 6(22) : 1008 - 1022.
  • 7Unden J, Romner B. Can low serum levels of S100b predict nor- mal CT findings after minor head injury in adults.'? An evidence - based review and meta - analysis [ J ]. J Head Trauma Rehabil, 2010, 25(4) : 228 -240.
  • 8Ohrt -Nissen S, Friis -Hansen L, Dahl B, et al. How does ex- tracerebral trauma affect the clinical value of S100b measurements [ J]. Emerg Med J, 2011,28 ( 11 ) : 941 - 944.
  • 9Donato R. Rage : A single receptor for several ligands and different cellular responses: the case of certain S100 proteins [ J ]. Curr Mol Med, 2007, 7(8) : 711 -724.
  • 10Villarreal A, Aviles Reyes R, Angelo M, et al. S100b alters neuronal survival and dendrite extension via rage - mediated NF - Kappab Signaling [ J ]. J Neurochem, 2011, 117 ( 2 ) : 321 - 332.

引证文献6

二级引证文献30

山东医药
2012年 第24期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部