摘要
本文报告157例Graves病患者六种自体抗体的测定结果,按临床表现、甲功测定及治疗情况分为未治组(甲)、治疗未控制或复发组(乙)、治疗缓解组(丙)三组。发现甲组患者TRAb、TgAb、TmAb、抗DNA抗体、ANA的阳性率分别为91.2、79.4、79.4、70.6及23.5％;抗体阳性率及结合率乙组与甲组比(除TBII P<0.05外)差异均无显著性;丙组与甲、乙两组相比其TRAb阳性率及TBII差异均有显著性(P<0.01),TmAb结合率与乙组比有显著差异(P<0.05),TgAb、TmAb、抗DNA抗体阳性率有显著差异(与甲组比P<0.01,与乙组比P<0.05);乙、丙两组IAb阳性率为5.6及4.2％。结果提示,Graves病患者血清中存有多种自体抗体,TRAb可作为检测Graves病及判断治疗效果和预后的一种可靠方法。经抗甲药物治疗后其IAb阳性率亦较高。
One hundred and fifty-seven cases of Graves' disease were divided into three groups according to their clinical features and thyroid functions: Group A, untreated; group B, treated but uncontrolled or relapsed; group C, treated and remitted. The positive rates of TSH receptor antibody (TRAb), anti-tnyroglobulin antibody (TgAb), anti-microsomal antibody (TmAb), anti-DNA antibody and anti-nuclear antibody (ANA) were 91.2, 79.4, 79.4, 70.6 and 23.5% respectively in group A. The positive rate of TRAb and TBII were significantly different between group C and group A or B (both P<0.01). There were significant differences in the positive rates of TgAb, TmAb, anti-DNA antibody between group C and group A or B (G vs A: P<0.01, C vs B: P<0.05). The positive rates of insulin antibody (lAb) were 5.6% and 4.2% in group B and G respectively. It indicated that many autoantibodies may be involved in Graves' disease, the measurement of TRAb is valuable for diagnosing Graves' disease, monitoring the therapeutic effect and predicting the prognosis. There is a high incidence of positive IAb in patients with Graves' disease after treated with antithyroid drugs.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1990年第2期72-74,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
自身抗体
测定
格雷夫斯病
Graves' disease TRAb TgAb TmAb Anti-DNA antibody ANA IAb
