摘要
目的探讨T2DM患者CA199水平与血糖、IR和胰岛β细胞功能之间的关系。方法入选T2DM患者165例,分别以HbA1c 10.1%、FPG 8.31mmol/L、胰岛素抵抗指数(HOMA-IR)2.7、胰岛功能指数(HOMA-islet)22.1为界,分为高HbA1c组(HH组)和低HbA1c组(LH组);高FPG组(HF组)和低FPG组(LF组);IR组和胰岛素敏感组(SR组);胰岛β细胞功能正常组(BN组)和胰岛β细胞功能减退组(BW组),比较各组CA199水平。结果 HH组CA199水平高于LH组(26.75 vs 16.68U/ml,P<0.05)。Spearman相关研究显示,CA199与HbA1c、FPG呈正相关(P<0.05),与IR、胰岛β细胞功能无相关性(P>0.05);多元逐步回归分析显示,HbA1c是CA199的主要影响因素。结论 T2DM患者CA199水平与血糖状态密切相关。
Objective To investigate the relations of CA199 level with blood glucose, insulin resistance, and β cell function in patients with type 2 diabetes mellitus. Methods The 165 hospitalized patients with type 2 diabetes were enrolled. They were divided into high glycosylated hemoglobin group （HH） and low glycosylated hemoglobin group （LH） at the cut level of HbA1 c 10. 1 %, into high fasting blood glucose group （HF） and low fasting blood glucose group （LF） at the cut level of FPG 8. 31 mmol/L, into insulin resistance group （IR） and insulin sensitivity group （SR） at the cut level of HOMA- IR 2. 7, and into normal β cell function group （BN） and low β cell function group （BW） at the cut level of HOMA-β 22.1. The CA199 level among the four groups was compared. Results The CA199 level of the HH group at 26. 75 U/ml was significantly higher than the LH group at 16. 68 U/ml （P〈0. 05）. Spearman relation analysis showed that the CA199 level was positively correlates with HbA1 c and FPG （P〈0. 05）, but not correlated with IR and 13 cell function （P〉0. 05）. Multiple stepwise regression analysis showed that HbA1 c was the main risk factor for CA199. Conclusion The CA199 level in patients with type 2 diabetes closely correlates with the state of blood glucose.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2012年第7期493-495,共3页
Chinese Journal of Diabetes
关键词
CA199
空腹血糖
HBA1C
胰岛素抵抗
胰岛Β细胞功能
CA199
Fasting blood glucose
Glycosylated hemoglobin （ HbA1 c ）
Insulin resistance
β cell function
