摘要
目的观察电针治疗对T10脊髓全横断尿潴留大鼠模型早期尿动力学指标的影响。方法将SD雌性大鼠31只按随机数字表法为假手术组（n=10）、模型组（n=11）和电针组（n=10），模型组和电针组建立脊髓全横断尿潴留大鼠模型，假手术组暴露T0、T10、T11的横突与棘突，不做任何损伤处理，于5min后直接缝合。电针组大鼠取“关元”、“三阴交”穴，采用连续波持续电刺激15min，每日治疗1次，连续治疗7d。假手术组和模型组进常规饲养。3组大鼠均于造模成功后第9天进行尿动力学检查。结果造模成功后第9天，电针组的残余尿量和膀胱容量分别为（2．79±0．59）ml和（4．60±0．73）ml，明显优于模型组的（5．18±0．61）ml和（6．43±0．85）ml，差异有统计学意义（P〈0．01）；而假手术组的残余尿量和膀胱容量最小，分别为（0．09±0．01）ml和（1．21±0．27）ml，与电针组和模型组比较，差异均有统计学意义（P〈0．01）。电针组的排尿量和排尿率分别为（1．81±0．15）ml和（39．89±3．18）％，明显优于模型组的（1．26±0．29）ml和（19．56±2．56）％，差异有统计学意义（P〈0．01）；而假手术组的排尿率为（92．10±1．52）％，与电针组和模型组比较，差异均有统计学意义（P〈0．01）。电针组的漏尿点膀胱压和膀胱顺应性分别为（11．22±1．66）cmH2O（1cmH2O=0．098kPa）和（0．35±0．19）ml／cmH2O，明显优于模型组的（14．00±1．39）cmH2O和（0．45±0．20）ml／cmH2O，差异有统计学意义（P〈0．01）；而假手术组的漏尿点膀胱压和膀胱顺应性最低，分别为（5．00±1．00）cmH2O和（0．24±0．14）ml／cmH2O，与电针组和模型组比较，差异均有统计学意义（P〈0．01）。结论电针治疗可改善脊髓全横断大鼠早期的膀胱逼尿肌低反射状态和排尿功能。
Objective To observe the effect of electroacupuncture on urodynamic alteration in rats after complete T10 spinal cord transection. Methods Thirty-one female Sprague-Dawley rats were divided randomly into a sham operation group （n=10）, a model group （n =11） and an electroacupuncture （EA） group （n=10）. The spinal cords of the rats in the latter two groups were completely transected at the T10 level. Pressure was applied to the rats＇ lower abdomens every day while in the EA group electroacupuncture with continuous wave electricity was applied to the guanyuan （RN4） and sanyinjiao （SP6） acupoints for 15 min. The treatment was carried out daily for consecutive 7 days. Urodynamic examinations were carried out after the treatment course had finished. Results At the 9th day after the operation, average residual urine volume and bladder capacity in the EA group were both significantly lower than in the model group. Residual urine volume and bladder capacity were lowest in the sham operation group. Average voided volume and voiding rate in the EA group were significantly higher than in the model group. The average voiding rate was highest in the sham operation group. The average vesical pressure of the urine leak point and bladder compliance of the EA group rats Were significantly lower than those of the model group The average vesical pressure of the urine leak point and bladder compliance of the sham operation group were lowest of all. All of these differences were statistically significant at the 1% level of confidence. Conclusion EA can improve the lower bladder＇s detrusor reflex state and urinary tract function soon after complete T10 spinal cord transaction, at least in rats.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2012年第6期411-414,共4页
Chinese Journal of Physical Medicine and Rehabilitation
基金
基金项目：南京中医药大学青年自然科学基金项目（09XZR12）
关键词
脊髓损伤
尿潴留
电针疗法
尿动力学
Spinal cord injuries
Urinary retention
Electroacupuncture
Urodynamics
