摘要
目的:回顾性分析系统性红斑狼疮(SLE)并发感染患者的感染特点及危险因素。方法:选取2006年1月～2010年12月在我院住院的SLE患者81例,收集临床及实验室资料,临床资料主要包括患者性别、年龄、糖皮质激素用量、疗程,环磷酰胺等免疫抑制剂使用、感染情况等。实验室指标有血常规、血沉、超敏C反应蛋白、血脂(三酰甘油、胆固醇)、血白蛋白、病原学结果等,观察感染部位、病原菌特点及各因素对SLE感染发生率变化的影响。结果:(1)大部分感染以细菌为主,占53.4%,同时以肺炎克雷伯氏菌为主的G-菌占绝大多数;真菌以念珠菌属最常见,且多见于50岁以上SLE患者;巨细胞病毒感染是SLE感染患者主要的病毒检出类型。(2)SLE以呼吸道感染占绝大多数,其次尿路感染在SLE患者也不少见,带状疱疹是最常见的皮肤感染表现。(3)与SLE非感染患者比较,老年患者、CRP增高、血白蛋白下降者感染发生率明显升高,差异有统计学意义。其中>50岁SLE患者感染危险度是年轻患者的6.44倍,血白蛋白下降患者感染风险较正常增加1倍。而性别、ESR、血脂等因素改变与感染无明显相关性。结论:贫血对感染的发生率改变无明显影响。CRP增高与SLE的活动状态无明显关系。
Objective：To analyze infection characterizes and risk factors of systemic lupus erythematosus （SLE） with infec- tion. Methods：From Jan 2006 to Dec 2010, a total of 81 SLE patients treated in our hospital were collected clinical and laboratory da- ta. Clinical data including sex, age, glucocorticoid dosage, treatment period with cyclophosphamide or other immunosuppressive a- gent, infection, etc; Laboratory includ Blood routine test, ESR, C- reactive protein, blood lipids （triglycerides, cholesterol）, serum albumin, bacterium test. To observe the infection site, pathogen characteristics and the factors on the incidence of SLE infection effects of changes in . Results： （1）534% patients infected bacteria, mainly with Klebsiella pneumonia. Patients （ 〉 50 years old） mainly infected Candia, mainly common fungus. CMV infeetion is a major SLE virus -infected patients detected type. （2）Patients had respiratory infection mostly, secondly urinary tract infections, Skin manifestations mainly were herpes zoster. （ 3 ） SLE patients with older ages, lower blood albuim, higher CRP would easiler have infections compared with patients without infeetions（ P 〈 0.05 ）. Condusion：Patients＇ses, ESR, blood lipids, anemia had no relationship with infection. Higher CRP had no use to action of the SLE.
出处
《中国中西医结合肾病杂志》
2012年第5期420-422,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
关键词
系统性红斑狼疮
感染
临床特点
Systemic lupus erythematosus infection Chinical Characteristics
