摘要
气道上皮细胞是肺天然免疫系统的重要组成部分，通过模式识别受体识别病原相关分子模式，启动天然免疫反应，随后通过抗原呈递和共刺激信号，活化获得性免疫反应。气道上皮细胞的天然免疫反应与抵御病原菌高度相关。本文就气道上皮细胞对细菌病原的天然免疫应答研究进展作一综述。
Airway epithelial cells are an important part of the lung innate immune system, they recognize conserved structures in microorganisms, called pathogen-associated molecular patterns through apically exposed and intracellular receptors, called pattern recognition receptors and initiate innate immune response. Subsequently, they activate adaptive immnue response through antigen presentation and co-stimulatory signals. Innate immune responses of the airway epithelium play a critical role in resisting pathongens. The research progress of innate immune response in the airway epithelium fight against respiratory bacterial pathongens is reviewed here.
出处
《国际呼吸杂志》
2012年第10期779-783,共5页
International Journal of Respiration
关键词
气道上皮细胞
细菌病原
天然免疫
Airway epithelium
Bacterial pathongens
Innate immune
