摘要
目的:观察氨氯地平联合辛伐他汀逆转高血压导致的左心室肥厚和改善左心室功能的效果。方法:将2008年3月-2010年8月在我院确诊为高血压合并左心室肥厚患者165例,随机分为氨氯地平组和氨氯地平+辛伐他汀组,分别应用氨氯地平5mg.d-1和氨氯地平5mg·d-1+辛伐他汀10mg·d-1治疗,治疗前和随访结束时采用西门子彩色多普勒超声心动图测量患者心脏结构指标。结果:治疗后,2组患者收缩压和舒张压较治疗前均显著降低(P<0.05),但2组同期比较差异无统计学意义(P>0.05);2组室间隔厚度、左心室后壁厚度、左心室质量、左心室质量指数均显著降低(P<0.05),且氨氯地平+辛伐他汀组优于氨氯地平组(P<0.05);2组均能显著增加射血分数(EF)、舒张早期二尖瓣血流速度与舒张晚期二尖瓣血流速度比值(E/A)(P<0.05),且与氨氯地平组比较,氨氯地平+辛伐他汀组可进一步增加EF和E/A(P<0.05)。2组均未见严重不良反应发生。结论:氨氯地平联合辛伐他汀治疗高血压合并左心室肥厚患者能有效降压和逆转左心室肥厚,进而改善心功能。
OBJECTIVE： To verify and investigate whether simvastatin could reverse left ventricular hypertrophy and improve left ventricular function. METHODS： 165 hypertension patients with left ventrieular hypertrophy were collected from our hospital during Mar. 2008--Aug. 2010. They were randomly divided into 2 groups, i.e. amlodipine group （5 mg.d^-1） and amlodipine （5 mg·d^-1） combined with simvastatin （10 mg·d^-1） group. Before treatment and at the end of following-up, the structure of the heart was measured by using Siemens color Doppler echocardiogram. RESULTS： After treatment, systolic and diastolic pressures of patients in 2 groups were declined （P〈0.05）. There was no statistical significance in systolic and diastolic pressures before and after treatment （P〉0.05）. IVST, LVPwT, LVM, LVMI,EF and E/A ratio were also decreased significantly （P〈0.05）. After treatment, the above parameters of amlodipine combined with simvastatin group were further decreased （P〈0.05）. Amlodipine treatment and amlodipine combined with simvastatin treatment could improve EF and E/A ratio in hypertension patients with left ventricular hyper- trophy （P〈0.05）. Compared with amlodipine group, amlodipine combined with simvastatin could further improved EF and E/A ratio （P〈0.05）. There was no serious ADRs found in 2 groups. CONCLUSION： Amlodipine combined with simvastatin can reverse left ventricular hypertrophy and improve blood pressure effectively.
出处
《中国药房》
CAS
CSCD
2012年第24期2259-2260,共2页
China Pharmacy
关键词
氨氯地平
辛伐他汀
高血压
左心室肥厚
心功能
Amlodipine
Simvastatin
Hypertension
Left ventricular hypertrophy
Heart function
