摘要
目的采用HPLC法测定扎托布洛芬缓释胶囊的含量。方法采用Kromasil C18(150 mm×4.6 mm,5μm)色谱柱,流动相为乙腈-水-冰醋酸(300∶200∶1),流速1.0 mL·min-1,检测波长240 nm。结果 5～35μg·mL-1扎托布洛芬与峰面积呈良好的线性关系(r=0.9999),平均回收率为99.03%,RSD=0.52%。结论所用方法准确可靠,简便,快速,适用于扎托布洛芬缓释胶囊的质量控制。
OBJECTIVE To develop an HPLC method for determination of the content of Zaltoprofen（ZP） sustained-release capsules.METHODS Chromatographic conditions included a Kromasil C18 column（150 mm×4.6 mm,5 μm）,and the mobile phase consisted of acetonitrile-water-acetic acid（300：200：1）.The flow rate was 1.0 mL·min-1,and the detective wavelength was 240 nm.RESULTS The good linear relationship was within the range of 5~35 μg·mL-1（r=0.9999）.The average recovery of ZP was 99.03%（RSD=0.52%）.CONCLUSION The method is accurate,simple,and rapid.It can be used to determine the content of ZP sustained-release capsules.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2012年第3期330-331,共2页
West China Journal of Pharmaceutical Sciences
基金
四川省卫生厅课题(编号:080098)
