摘要
目的:观察阿托伐他汀联合苯扎贝特治疗混合性高脂血症的疗效及安全性。方法:混合性高脂血症80例,随机分为2组:联合组晨起口服苯扎贝特200 mg,晚上睡前服用阿托伐他汀10mg;对照组单用阿托伐他汀10mg,每晚一次顿服。观察两组用药8周后血脂水平变化及不良反应情况。结果:治疗8周后于治疗前相比联合组总胆固醇(TC),甘油三酯(TG),低密度脂蛋白(LDL-C)显著降低(P<0.01),高密度脂蛋白(HDL-C)明显升高(P<0.05);对照组TC,LDL-C明显降低,(P<0.05)。两组间比较:联合组TG,TC,LDL-C显著降低,(P<0.01),HDL-C水平明显升高(P<0.01)。两组不良反应无明显统计学差异。总有效率联合组为77.5%,对照组为67.5.0%,有显著性差异(P<0.01)。结论:阿托伐他汀联合苯扎贝特给药对混合性高脂血症的疗效确切。但应注意掌握适应症和服药方法,尽可能减少联合用药引起的不良反应。
Objective：To observe the effectiveness and safety of atorvastatin combined with bezafibrate in treatment of hyperlipidemia.Methods：80 cases of mixed hyperlipidernia were randomized to two groups,40 cases in each.The combined group was treated with 200mg bezafibrate in the morning,with 10mg atorvastatin in the evening.The control group took 10mg atorvastatin every night.To observe the changes in blood lipid levels and adverse reaction after 8 weeks.Results：TC,TG,LDL-C levels declined significantly（P0.01）,and HDL-C levels was higher in combined group（P0.05）;TC,TG,LDL-C level was dramatically declined in the control group（P0.05）.Compare the two groups： the TC,TG,LDL-C levels was significantly lower（P0.01） and HDL-C level was significantly higher in the combined group（P0.01）.There is no significant adverse reaction between the two groups.The total effective rate is 77.5% in combined group and 67.5% in control group.Conclusion：The effect of atorvastatin combined with bezafibrate in the treatment of mixed hyperlipidemia is reliable,but should keep close watch on the indication in order to decrease the adverse reation.
出处
《中国医药导刊》
2012年第5期838-839,共2页
Chinese Journal of Medicinal Guide
