摘要
目的探讨强化血液灌流和普通血液灌流治疗急性百草枯中毒患者的疗效。方法回顾分析百草枯中毒患者52例,根据治疗方式分为两组:A组为强化灌流组(n=28),每日行2次血液灌流,持续一周;B组为普通灌流组(n=24),每日行1次血液灌流治疗,持续一周;除了血液灌流外,两组患者的常规治疗均相同。对两组患者的死亡率和各个器官的并发症发生率进行比较;对两组患者的血白细胞、动脉血氧分压、C反应蛋白、肌酐、视黄醇结合蛋白的水平进行比较。结果 A组和B组的死亡率、急性肾损伤发生率、急性呼吸窘迫综合征发生率比较,差异有统计学意义(χ2分别=6.39、7.08、6.39,P均<0.05)。A组的血白细胞及C反应蛋白水平明显低于B组(t分别=5.06、5.57,P均<0.05),氧分压明显升高(t=7.02,P<0.05),血肌酐和视黄醇结合蛋白水平明显下降(t分别=3.61、10.81,P均<0.05)。结论和普通血液灌流相比,强化血液灌流可进一步降低百草枯中毒患者的死亡率,减少心肺和肾脏并发症的发生率。此外,强化灌流还可进一步降低白细胞及C反应蛋白水平,改善氧合。
Objective To evaluate the effect of intensive hemoperfusion（IHP） in the treatment of acute paraquat poisoning. Methods Fifty-two patients diagnosed as acute paraquat poisoning were included in the study. The patients were divided into two groups ：group A （intensive hemoperfusion,2 times everyday for one week,n =28）,group B （conventional hemoperfusion,once everyday for one week,n=24）. Patients in the two groups underwent the same conventional treatment except for the HP. Mortality and complication rates were compared among the two groups, and white blood cell （WBC）, arterial oxygen partial pressure （PaO2）, C-reactive protein （CRP）, serum creatinine （Cr）, retinol-binding protein （RBP） were analyzed. Results The mortality rates, incidence of acute kidney injury, incidence of ARDS had statistic differences between group A and group B （X2=6.39,7.08,6.39,P〈0.05）. Compared with group B,the level of WBC and CRP in group A was significantly reduced （t=5,06,5.57,P〈0.05） and the level of PaO2 was increased （t=7.02,P〈0.05）. The level of serum Cr and RBP were significantly reduced （t=3.61,10.81 ,P〈0.05）. Conclusions Compared with traditional hemoperfusion, intensive hemoperfusion can significantly redueed the mortality in the patients with paraquat poisoning. Further more,the intensive hemoperfusion can significantly lower the level of WBC and CRP and improve the oxygenation.
出处
《全科医学临床与教育》
2012年第3期262-264,共3页
Clinical Education of General Practice
关键词
强化血液灌流
百草枯
死亡率
intensive hemoperfusion
paraquat
mortality rate
