摘要
背景缺血性心脏病被认为是世界范围内人类发病和死亡的主要原因；预处理，包括缺血预处理（ischemicpreconditioning，IP）和药物预处理在正常心肌中的保护作用已得到证实。目的了解合并心血管相关危险因素等病理条件下预处理对心脏缺血，再灌注（ischemia／reperfusion，I／R）的影响。内容就近年来在某些病理状态下（如高血脂、糖尿病、高血压、老龄化及肥胖等）预处理对心脏缺血／再灌注损伤（ischemia／reperfusioninjury，I／RI）的作用及可能机制的研究简要作一综述。趋向为进一步研究相关的心脏保护策略提供思路。
Background Ischemic heart diseases have been remarked as the primary cause of morbidity and mortality worldwide. The protective role of preconditioning including ischemia preconditioning and pharmacological preconditioning on isehemia/reperfusion injury （I/RI） has been confirmed. Objective To understand the effects of preconditioning on myocardial I/RI of those associated with cardiovascular risk factors. Content In the present review, we will briefly talk about the studies of the effects and possible mechanisms of preconditioning in some pathological conditions such as hypercholesterolemia, hyperglycemia, hypertension,aging and obesity in recent years. Trend To offer some heart protection study strategies.
出处
《国际麻醉学与复苏杂志》
CAS
2012年第6期420-422,434,共4页
International Journal of Anesthesiology and Resuscitation
关键词
预处理
再灌注损伤
心脏
心血管危险因素
Preconditioning
Reperfusion injury
Heart
Cardiovascular risk factor
