摘要
目的:研究儿童铅中毒的智力改变与脑诱发电位的关系,探索儿童铅中毒的神经毒性和心理行为改变的电生理依据。方法:通过测定血铅及社会家庭情况问卷调查,在排除了影响智力的几个重要因素后,把6～12岁的45例符合条件的儿童分为高铅组(血铅值≥10μg/dl)和正常组(血铅值<10μg/dl),进行韦氏智力量表(WISC)的测定及体感诱发电位(SEP)和事件相关电位(ERP)P300的检测。全面评价铅中毒对儿童智力、感觉系统、高级神经功能的损害程度。结果:铅中毒儿童的总智商和言语智商较正常儿童显著降低,有统计学差异。操作智商虽也有降低,但与正常对照组相比无统计学差异。铅中毒儿童SEP的早期皮层电位P15、N20、P25与正常对照组相比无明显改变,但晚期皮层电位有明显异常,主要表现在N35、P45、和N60的潜伏期延长。铅中毒儿童的P300各波中,N100、P200与正常对照组相比无明显差别,但P300及N200的波幅较正常儿童明显降低,潜伏期也明显延长。结论:上述研究为儿童铅中毒的神经毒性和认知心理行为的异常提供了具有客观性的电生理依据,为儿童铅中毒的神经毒性的预防、诊断和治疗的观察提供了电生理依据。
Objective： To study the relationship between intelligent change and brain evoked potential among the children with lead poisoning, explore the electrophysiological basis of neurotoxicity and psychological and behavioral changes among the children with lead poi- soning. Methods： According to the blood lead levels, social and family investigation with a questionnaire, after excluding several important effect factors of intelligence, forty -five children aged 6 - 12 years meeting the criterion were divided into high lead group （blood lead level≥ 10 μg/dl） and normal group （blood lead level 〈 10 μg,/dl） . The children were detected by WISC, sensory evoked potential （SEP） detection, and eventrelated potentials （ERP） detection, respectively. The degrees of injuries of lead poisoning to intelligence, sensory system, and advance mental function were entirely evaluated. Results： The full scale intelligence quotient and verbal intelligence quotient of high lead group were significantly lower than those of normal group. The performance intelligence quotient decreased, but there was no significant difference between the two groups. There was no significant difference in P15, N20, P25 of early cortical potential of SEP between the two groups, but there was significant difference in late cortical potential, the elongation of N35, P45, and N60 was the main manifestation. Among P300 waves, there was no significant difference in N100 and P200 between the two groups, but the amplitudes of P300 and N200 decreased significantly, and the latent period extended obviously. Conclusion ： The study provides an objective and electrophysiological basis for neurotoxicity and abnormality of cognitive and psychological behaviors of children with lead poisoning, observing prevention, which also provides electro- physiological basis for diagnosis, and treatment of lead poisoning among children.
出处
《中国妇幼保健》
CAS
北大核心
2012年第16期2462-2464,共3页
Maternal and Child Health Care of China
关键词
儿童铅中毒
神经毒性
神经心理缺陷
智力测定
Children with lead poisoning
Neurotoxicity
Neuropsychological deficiency
Intelligent detection
