摘要
目的 :探讨温州地区绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)与雌激素受体(estrogen receptor,ER)α基因多态性及相关因素。方法:将纳入研究的203例绝经女性按标准分为骨量正常组、骨量减少组与PMOP组。分别检测各观察对象的腰椎L1～4骨密度、PvuII、XbaI基因型并调查其膳食行为与运动方式等项目。结果:结果显示年龄越大、文化程度越低、身材矮小及BMI越低、多妊娠次数、多产次者与PMOP的发生率有关。摄入牛奶、豆浆、茶、水产品、豆类、肉类、蛋类、水果、坚果及每月运动次数越多与高骨密度有关。PvuII基因型中PP、pp、Pp的频率分别为26.6%、27.6%及45.8%;XbaI基因型XX、xx、Xx的频率分别为9.9%、57.1%及33%。多因素分析表明年龄因素、咖啡饮用量、XbaI的XX基因型是骨量减少的危险性因素;文化程度越高、BMI较大、经常饮茶或经常摄入水果是PMOP的保护因素。结论:本地区膳食行为、环境因素与PMOP间关系密切,但ERα基因型分布频率不同于其他地区且与骨密度间关系尚不明确,其对骨质疏松发病的预测价值有待深入研究。
Objective： To probe the relationship between postmenopausal osteoporosis（PMOP）and the estrogen receptor α gene polymorphisms and other relevant factors.Methods： Two hundred and three postmenopausal women were randomly selected and devided into nomal control group,bone loss group and PMOP group.Lumbar BMD was measured,and genotypes were detected.Meanwhile,the dietary behavior and exercise of the women were also surveyed.Results： Age,lower educational level.shorter height,lower weight,BMI,more pregnancies and childbirth were related with PMOP.Intake of more milk,soy milk,tea,sea food,beans or bean products,meet,eggs,fruit,nuts and more exercise monthly were associated with high BMD.The frequencies distribution of PvuII was PP：26.6%,pp：27.6% and Pp：45.8%,respectively,and the frequencies distribution of XbaI was XX：9.9%,xx：57.1% and Xx：33%,respectively.Logistic regression indicated that age,coffee and XbaI XX were the risk factors of bone loss,the high degree of culture,BMI,often drinking tea or intake of fruit were the protection factors of PMOP.Conclusion： The frequen-cies distribution of ERα is different from other regions,and the relationship between BMD is not clear,the predictive value on PMOP remains to need further study.Close relationship between and dietary behavior and environmental factors is found in our rcescarch.
出处
《温州医学院学报》
CAS
2012年第3期237-241,245,共6页
Journal of Wenzhou Medical College
基金
温州市科技局科研基金资助项目(Y20060109)
浙江省中医药管理局科研基金资助项目(2007CB179)
温州市鹿城区科技局科研基金资助项目(S080113)
关键词
绝经后骨质疏松症
雌激素受体
基因多态性
骨密度
饮食行为
postmenopausal osteoporosis
estrogen receptor
gene polymorphisms
bone min-eral density
dietary behavior
