摘要
目的探讨新疆维吾尔族、汉族变应性鼻炎患者IL-4和IgE的表达水平及其相关性。方法选择新疆维吾尔族(维族)AR患者47例,健康对照组46例;汉族AR患者45例,健康对照组45例采用双抗体夹心酶联免疫吸附剂测定法(ABC-ELISA)检测IL-4和IgE的表达水平,并对变应性鼻炎患者IL-4与IgE进行相关性分析。结果维、汉族变应性鼻炎组血清中IL-4、IgE水平明显高于维、汉族健康对照组,差异有统计学意义(P<0.05),维吾尔族、汉族变应性鼻炎组IL-4与IgE水平呈正相关关系(r分别为0.414、0.393,P<0.01),维、汉族AR组及维、汉族健康对照组之间血清IL-4水平差异无统计学意义(P>0.05),维、汉族AR组及维、汉族健康对照组之间血清IgE水平差异有统计学意义(P<0.05)。结论 IL-4和IgE在维、汉族变应性鼻炎发病过程中均发挥重要作用。
Objective To investigate the correlation of Interleukin-4（IL-4） and Immunoglobulin E（IgE） levels presented in Xinjiang Uighurs and Han people with allergic rhinitis（AR）.Methods The levels of IL-4 and IgE among 47 cases of AR patients and 46 healthy controls of Uighurs nationality and 45 cases of AR and 45 cases,healthy controls of the Han nationality were tested by double antibody sandwich enzyme league immune adsorbent measurement（ABC-ELISA）.Results The levels of IL-4 and IgE were significant higher than the healthy control group（P0.05）.IL-4 had positive correlation with IgE（r=0.414,r=0.393,P0.01）.The levels of IL-4 was not statistical significance between Uighur and Han with allergic and Uighur and Han nationality group（P0.05）.The levels of IL-4 in Uighurs nationality and Han nationality in both AR and healthy control group were statistical significances（P0.05）.Conclusion This essay proves that IL-4 and IgE play important roles in the course of AR in Xinjiang Uighurs and Han people.
出处
《新疆医科大学学报》
CAS
2012年第4期439-441,456,共4页
Journal of Xinjiang Medical University
基金
国家自然科学基金项目(30960415)
新疆维吾尔自治区自然科学基金资助项目(200821136)
关键词
变应性鼻炎
白介素4
抗免疫球蛋白E
酶联免疫吸附测定法
allergic rhinitis
Interleukin-4（IL-4）
Immunoglobulin E（IgE）
enzyme linked immunosorbent assay
