摘要
目的探讨传染性单核细胞增多症（infectiousmononucleosis，IM）患儿T细胞亚群的变化。方法选取2005年1月至2010年12月在我院住院确诊为Epstein—Barr（EB）病毒感染引起的IM患儿60例为IM组，同期来我院门诊健康体检患儿36例为对照组。所有患儿行血常规、血涂片、T细胞亚群、肝肾功能及病毒抗体、肝炎病毒抗体检测。T细胞亚群检测包括CD3、CD4、CD8、CD4／CD8。结果与对照组比较，IM组患儿CD3（81．55％±9．04％）、CD8（58．13％±13．35％）比例较对照组（53．58％±5．97％）、（31．22％±8．72％）明显升高（P〈0．05）；CD4（18．19％±7．61％）、CD4／CD8（0．37±0．33）比值较对照组（36．98％±5．32％、1．98±0．41）明显降低（P〈0．05）。IM组患儿白细胞计数、异型淋巴细胞比值及谷丙转氨酶与CD4／CD8的下降无相关性（P均〉0．05）。结论EB病毒感染引起IM患儿免疫功能显著低下，可早期进行免疫干预治疗。
Objective To investigate the change of T-lymphocyte subgroup in children with infectious mononucleosis（IM）. Methods Sixty young children with IM caused by Epstein-Barr virus （EBV） were recruited for this study in Jiaxing First Hospital from Jan 2005 to Dec 2010. Thirty-six normal children were chosen as control group. Both of the two groups were detected blood test, blood smear, T-lymphocyte subgroup （ including CD3, CD4, CD8, CD4/CD8 ）, liver and kidney function test, IgM antibodies of EBV, cytomegalovirus, adenovirus, and hepatitis virus. Results Compared with the control group （53.58% ± 5.97% ,31.22% ±8. 72% ） ,the ratio of CD3 （81.55% ±9. 04% ） and CD8（58. 13% ± 13. 35% ） were significantly higher in IM group（P 〈0. 05）. And the ratio of CD4 （18. 19% ±7.61% ） and CD4/CD8 （0. 37 ± 0. 33） were significantly lower in IM group, compared with the control group （36. 98% ± 5.32%, 1.98 ±0.41 ） （ P 〈 0.05 ）. While the leukocyte count, the ratio of abnormal leukomonocyte, and alanine transaminase had no correlation with the decrease of CD4/CD8 （ P 〉 0. 05 ）. Conclusion Children with IM caused by EBV have bad immunocompetence, and we can treat them with immunotherapy early.
出处
《中国小儿急救医学》
CAS
2012年第2期166-167,共2页
Chinese Pediatric Emergency Medicine
