摘要
目的 探讨急性冠状动脉事件血浆纤溶系统的变化及其临床意义。方法 测定并比较急性心肌梗塞组 (n =2 4)、不稳定性心绞痛组 (n =2 0 )、稳定性心绞痛组 (n =30 )和健康对照组 (n =2 0 )患者的血浆组织型纤溶酶原激活物、纤溶酶原激活物抑制物、D 二聚体和纤维蛋白原的浓度。结果 急性心肌梗塞组和不稳定性心绞痛组患者血浆组织型纤溶酶原激活物活性显著低于稳定性心绞痛和健康对照组 (P <0 .0 1) ;急性心肌梗塞组和不稳定性心绞痛组患者纤溶酶原激活物抑制物、D 二聚体和纤维蛋白原的活性均显著高于稳定性心绞痛和健康对照组 (P <0 .0 5或 0 .0 1) ,而急性心肌梗塞组与不稳定性心绞痛组 ,稳定性心绞确组与健康对照组患者之间上述指标差异无显著性 (P >0 0 5 )。结论 急性心肌梗死和不稳定性心绞痛患者存在纤溶活性减低 ,可能是血栓形成的重要因素之一。
Objective To determine changes and clinical significance of fibrinogen system in acute coronary syndromes. Methods Plasma tissue type plasminogen activator (t PA), Plasminogen activator inhibitor (PAI), D Dimer and fibrinogen (FG) were determined in 24 patients with acute myocardial infarction (AMI), 20 patients with unstable angina pectoris (UAP), 30 patients with stable angina pectoris (SAP) and 20 normal populations. Results The plasma t PA activity in patients with AMI and UAP were significantly lower than the patients with SAP and control group. The plasma PAI activity, concentrations of D dimer and fibrinogen in patients with AMI and UAP were significantly higher than the patients with SAP and control group. However, there were no significant differences in the patients with AMI and UAP, as well as the patients with SAP and control group. Conclusion The results manifest the patients with AMI and UAP show a reduced fibrinolytic activity. Which may be one of the important factors resulting in the development of intra coronary thrombi.
出处
《中国介入心脏病学杂志》
2000年第2期71-72,共2页
Chinese Journal of Interventional Cardiology
