摘要
目的:研究制备葛根素自微乳制剂。方法:根据葛根素的饱和溶解度选取油相、乳化剂和助乳化剂,通过伪三元相图,以自乳化效率及成乳后粒径为指标,确定最佳处方。结果:最佳处方为油酸乙酯∶吐温80/蓖麻油聚氧乙烯醚40(1∶2)∶聚乙二醇400∶葛根素∶三七总皂苷=15∶35∶35∶6∶9;微乳的平均粒径为32.9nm。结论:加入三七总皂苷的葛根素自微乳粒径小,稳定性好,这为自微乳制剂的增效减毒提供了新的思路和途径。
OBJECTIVE： To study on the preparation of Puerarin self-microemulsifying drug delivery system（SMEDDS） . METHODS： The oil phase,emulsifier and auxiliary emulsifier were selected according to the saturation solubility of puerarin. The optimal formulation was determined by pseudo-ternary phase diagram using self-emulsifying efficiency and the emulsion particle size as the index. RESULTS： The optimal formulation was ethyl oleate ∶ Tween-80/EL-40（1 ∶ 2） ∶ PEG 400 ∶ puerarin ∶ PNS=15 ∶ 35 ∶ 35 ∶ 6 ∶ 9. The average diameter was 32.9 nm. CONCLUSION： Puerarin SMEDDS added into Panax pseudoginseng total saponins has small particle size and sound stability,which provides new idea and channel for efficacy-increasing and toxicity-reducing of SMEDDS prepration.
出处
《中国药房》
CAS
CSCD
2012年第15期1375-1377,共3页
China Pharmacy
基金
山东省中医药科技发展计划项目(2009-086)
关键词
葛根素
自微乳给药系统
三七总皂苷
伪三元相图
减毒增效
Puerarin
Self-microemulsifying drug delivery system
Panax pseudoginseng total saponins
Pseudo-ternary phase diagram
Efficacy-increasing and toxicity-reducin
