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HSV-1感染后认知功能障碍小鼠海马组织细胞周期素依赖性蛋白激酶5mRNA的表达 被引量：2

The Expression of CDK5 mRNA in Hippocampal Tissue of Mice with Herpes Simplex Encephalitis
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摘要 目的探讨细胞周期素依赖性蛋白激酶5(CDK5)在单纯疱疹病毒-1型(HSV-1)感染后认知功能障碍小鼠海马组织中的表达变化及其作用。方法将雄性C57BL/6小鼠100只随机分为模型组、假手术组及正常组。采用颅内注射法建立单纯疱疹病毒性脑炎(HSE)动物模型,感染后20 d进行水迷宫实验评价认知功能,应用RT-qPCR方法检测小鼠海马组织CDK5 mRNA的相对表达量。结果与正常组及假手术组比较,模型组小鼠学习、记忆能力受损明显,模型组小鼠海马组织CDK5的表达水平明显升高(P<0.05)。结论 CDK5有可能参与了HSV-1感染后小鼠认知功能障碍的发生。 Objective To investigate the change of expression and possible effect of cyclin-dependent protein kinase 5（CDK5） in hippocampal tissue of mice with herpes simplex encephalitis.Methods One hundred male C57BL/6 mice were randomly divided into three groups：normal group,sham-operated group and model group.Herpes simplex encephalitis mice model was made by intracerebral inoculation.The behavioral tests were done respectively at 20 days after inoculation.Then the CDK5 mRNA expression was examined by RT-qPCR.Results Compared with the sham-operated group and normal group,the ability of learning and memory of model group was significantly damaged（P 0.05）.Expression of CDK5 mRNA in model group was significantly higher than the sham-operated group and normal group（P 0.05）.Conclusion CDK5 was involved in the cognitive deficits of mice with herpes simplex encephalitis.
作者 赵春梅 刘强 惠晶 王振海
机构地区 宁夏医科大学 宁夏医科大学总医院神经内科 宁夏回族自治区颅脑疾病重点实验室
出处 《中国医科大学学报》 CAS CSCD 北大核心 2012年第3期208-210,219,共4页 Journal of China Medical University
基金 教育部春晖计划资助项目(Z-2008-1-75002) 宁夏医科大学面上项目(XM200954)
关键词 单纯疱疹病毒-1型 认知功能障碍 细胞周期素依赖性蛋白激酶5 herpes implex virus-1 cognitive deficits CDK5
分类号 R74 [医药卫生—神经病学与精神病学]
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参考文献6

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二级参考文献12

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共引文献1

同被引文献32

  • 1郭斌,王爱芹,郭丽华,迟兆福,王淑贞.单纯疱疹病毒性脑炎的脑电图、P_(300)和临床[J].现代电生理学杂志,1998,5(2):57-59. 被引量：1
  • 2张玲,唐久来,吴德,许晓燕,盛晓蓉,杨世炳.阿昔洛韦治疗单纯疱疹病毒Ⅰ型脑炎小鼠血清一氧化氮、白细胞介素-1β水平变化及病理学观察[J].实用儿科临床杂志,2007,22(6):447-448. 被引量：7
  • 3彭争荣,肖平田.高压氧对病毒性脑炎患者智力和记忆的影响[J].中华物理医学与康复杂志,2007,29(6):413-415. 被引量：5
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中国医科大学学报
2012年 第3期

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