摘要
目的评价早产低出生体重儿出生时宫内生长受限(IUGR)和出院时宫外生长迟缓(EUGR)的发生情况。方法广州市、佛山市10家医院新生儿科出院的早产低出生体重儿(胎龄<37周,体重<2500g),分别以出生时、出院时生长发育指标在相应宫内生长速率期望值的第10百分位水平以下定义为IUGR、EUGR,分别计算各胎龄组、各体重组IUGR、EUGR发生率及总的发生率,并计算各胎龄组、各体重组EUGR发生率比IUGR发生率增加的比例。结果共595例早产低出生体重儿,出生时以体重、身长、头围为指标的IUGR发生率分别为20.2%、16.5%和24.4%,出院时以体重、身长、头围为指标的EUGR发生率分别为42.2%、28.1%和34.3%。不同出生胎龄(<31周、31～32周、33～34周、≥35周)出院时EUGR发生率较出生时IUGR发生率变化的情况:以体重为指标,EURG发生率各组分别增加36.8%、24.8%、19.1%、18.3%;以身长为指标,EUGR发生率各组分别增加26.5%、17.4%、8.2%、6.5%;以头围为指标,各组分别增加26.5%、14.0%、8.2%、3.2%,胎龄越小,增加率越高,组间比较差异有统计学意义(P<0.05)。不同出生体重(<1500g、1500～1999g、≥2000g)出院时EUGR发生率较出生时IUGR发生率变化的情况:以体重为指标,EUGR发生率分别增加45.3%、21.2%、17.4%;以身长为指标,EUGR发生率分别增加29.7%、14.8%、4.6%;以头围为指标,EUGR发生率分别增加26.6%、12.0%、4.3%,体重越低,增加率越高,组间比较差异有统计学意义(P<0.05)。结论早产低出生体重儿IUGR发生率较高,出院时EUGR发生率较IUGR发生率增高,且出院时EUGR发生率较出生时IUGR发生率的增加随出生胎龄和出生体重的降低而升高。
Objective To assess the incidences of intrauterine growth retardation （IUGR） andextrauterine growth retardation （EUGR） in preterm/low-birth-weight infants （ gestational age 〈 37 w, birth weight 〈 2500 g） in Guangzhou and Foshan city. Methods Preterm/low-birth-weight infant from ten hospitals from Guangzhou and Foshan City in Guangdong Province were chosen for this study. The growth values at birth and on discharge of each infant were compared to the expected values based on the intrauterine growth data and postmenstrual day on discharge. Growth retardation was defined as measured growth values （body weight, body length and head circumference） ≤ 10th percentile of the values（ growth expectation based on estimated postmenstrual age）. In each specific group, the number of infants with ≤ 10th percentile for each growth parameter was counted and the percentages of patients who had values ≤ 10th percentile at birth and on discharge were calculated. And the increasing incidence from IUGR to EUGR in each specific group was also calculated. Results A total of 595 preterm/low-birth-weight infant were chosen for this study. The incidence of IUGR was 20. 2%, 16.5% and 24. 4% assessed by body weight, body length and head circumference, respectively. The incidence of EUGR was 42.2%, 28.1% and 34.3 % assessed by body weight, body length and head circumference, respectively. In each group assigned by gestational age （ 〈 31 w,31 - 32 w,33 - 34 w,35 - 36 w） ,the increasing incidence from IUGR to EUGR was 36.8%, 24. 8%, 19. 1% and 18. 3% assessed by body weight; 26.5%, 17.4% ,8.2% and 6.5% assessed by body length; 26. 5% ,14.0% ,8.2% and 3.2% assessed by head circumference. In each group assigned by birth weight （ 〈 1500 g, 1500 -1999 g,2000 -2499 g） ,the increasing incidence from IUGR to EUGR was 45.3% ,21.2% and 17.4% assessed by body weight; 29.7% ,14. 8% and 4. 6% assessed by body length; 26.6%, 12. 0% and 4.3% assessed by head circumference. Assessment of the increasing incidence from IUGR to EUGR by each specific group and each growth parameter showed a significant correction （ P 〈 0.05 ）. Conclusions The incidences of IUGR in preterm/low-birth-weight infants were still high. The incidence of EUGR was more than that of IUGR upon discharge. There was an increasing in incidence from IUGR to EUGR with the decrease in gestational age and birth weight.
出处
《中国新生儿科杂志》
CAS
2012年第2期73-77,共5页
Chinese Journal of Neonatology
基金
广东省科技计划项目(粤科规划字[2011]97号)
广州市科技计划项目应用基础研究专项重点项目(2011J4100046)
广州市医药卫生科技项目(201102A213149)
关键词
婴儿
早产
婴儿
出生时低体重
宫内生长受限
宫外生长迟缓
Infant, premature
Infant, low birth weight
Intrauterine growth retardation
Extrauterine growth restriction
