摘要
目的探讨MTNR1B基因多态性与宁夏汉族2型糖尿病患者体内脂质谱的关系。方法依据病例-对照设计方法,采用全自动生化分析仪等技术检测2型糖尿病患者体内脂质谱;应用PCR-RFLP法对宁夏汉族2型糖尿病患者295例、正常对照239例的MTNR1B rs1387153基因多态性进行分析。结果两组人群的MTNR1B rs1387153 C/T位点基因型和等位基因频率比较差异无统计学意义(P>0.05)。三种基因型的TG比较差异有统计学意义(P=0.046),T型等位基因的TG水平高于C等位基因。Logistic回归分析显示与2型糖尿病密切相关的独立危险因素依次是TG(P=0.001)和腰围(P=0.027)。结论 MTNR1B rs138715基因多态性与宁夏地区汉族2型糖尿病不具有相关性,但与TG水平相关。
Objective To study the relationship between gene polymorphism of MTNR1B and type 2 diabetes mellitus（T2DM）,particularly with the lipid spectrum of T2DM in Ningxia Han population.Methods An automatic biochemical analyzer was used to determine the lipid spectrum of T2DM according to case-control design methods.The analysis samples include 295 patients of Han people in Ningxia regions were determined by PCR-RFLP and 239 genetic diversity of MTNR1B rs1387153 determined normally.Results There were no significant differences of genotype and allele frequency between the two groups in MTNR1B rs1387153 C/T（P0.05）,there was significant difference in genotype TG between three groups and the level of TG of allele T was higher than that of allele C.Logistic regression analysis showed T2DM was closely related to TG（P=0.001） and waist（P=0.027）.Conclusions Genetic diversity of MTNR1B rs1387153 is related with T2DM in Han people in Ningxia regions and is also related with the concentration of TG.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2012年第6期1119-1121,共3页
Chinese Journal of Gerontology
基金
国家自然科学基金资助(No.81061120527)
宁夏自然科学基金资助(NZ08145)
