摘要
目的观察右美托咪定预防小儿全麻苏醒期躁动的效果。方法选择ASA分级I～Ⅱ级在丙泊酚复合瑞芬太尼静脉全麻行腹股沟疝行常规手术的患儿60例。随机分为对照组(C组)和右美托咪定(D组)组各30例,麻醉前对照组注射生理盐水10 mL,右美托咪定组注射右美托咪定0.5μg/kg,两组患儿静脉注射瑞芬太尼0.5μg/kg和丙泊酚2 mg/kg麻醉诱导,麻醉维持采用静脉输注丙泊酚5 mg/kg.h和瑞芬太尼0.2μg/kg.min,在手术结束前15 min静脉注射芬太尼0.1μg/kg。记录小儿苏醒时(T0)、小儿苏醒后10 min(T1)、小儿苏醒后30 min(T2)、小儿苏醒后60 min(T3)的HR、Sp02。记录小儿苏醒时间、躁动评分及躁动例数。结果两组小儿苏醒后各时间点Sp02比较无统计学意义,但苏醒后各时间点右美托咪定组患儿的HR比对照组低,比较具有统计学意义。D组比C组的苏醒时间延长,具有统计学意义。美托咪定组患儿躁动评分比对照组低,两组间比较有统计学意义,躁动例数D组比C组明显少比较,比较有统计学意义(P<0.05)。结论术前静脉注射右美托咪定0.5μg/kg能有效预防小儿全麻术后躁动,且没有呼吸抑制作用,是预防小儿全麻术后躁动的一个很好选择。
[ Objective ] To observe the effect of Dexmedetomidine on recovery of general anesthesia in children. [ Methods ] 60 children of ASA （I-II） were scheduled to routine inguinal hernia during general anesthesia. They were randomly divided to two groups： The control group （C n =30） and the Dexmedetomidine group （D n =30）. The patients of group C were intravenously infused normal saline 10 ml and the patients of group D were intravenously infused Dexmedetomidine 0.5μg/kg. All patients were intravenous induction by remifentanil 0.51μg/kg and propofol 2 mg/kg. Anesthesia was maintained with intravenous infusion of propofol 5 mg·kg·h and remifentanil 0.2 μg/kg·min. All patients were intravenous infused fentanil 0.1μg/kg at 15 minutes before the end of surgery. Heart rate （HR） plus oxygen saturatio （SpOt） n were observed and recorded at wake-up after anesthesia （To）, 10 rain after wake-up （T1）, 30 rain after wake-up （T2）, 60 min after wake-up （T3）. Wake-up time, the cases of emergence agitation, the score of emergence agitation were observed and recorded. [Results] There was no difference on SpO2 in two groups of children. The HR in group D was significantly lower than that in group C. The wake-up time in group D was significantly longer than that in group C. The cases of emergence agitation and the score of emergence agitation were significantly lower than that in group C （P 〈0.05）. [ Conclusion ] Preoperative intravenous Dexmedetomidine 0.5μg/ kg could effectively prevent emergence agitation after general anesthesia in children and have no respiratory depression and in preventing emergence agitation after general anesthesia is a good choice.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第3期82-84,共3页
China Journal of Modern Medicine
