摘要
目的明确益生菌在重症急性胰腺炎患者中的作用效果。方法检索1966至2010年9月间Cochrane图书馆临床对照试验资料库（2010）、Medline（1966—2010．9）、中国期刊全文数据库、中文科技期刊数据库和万方数据库中发表益生菌作用于重症急性胰腺炎患者的临床随机对照试验，由2名研究者独立对文献进行质量评价和数据提取，并用RevMan4．3软件进行分析。结果共检索到313篇文献，剔除重复的和低水平文献，最后有6篇文献纳入研究，结果显示干预组并不能够降低重症急性胰腺炎患者的感染率（OR=0.88，95％CI[0．56，1．3s3）及死亡率（OR=1．44，95％cI[O．78，2．64]），但能够缩短住院时间（WMD=-4．69，95％CI[-7．73，-1．653），而干预组和对照组在全身炎性反应综合征（OR=1．33，95％CI[O．63，2．83]）、多器官功能衰竭（OR=1．50，95％CI[O．89，2．523）、转外科治疗（OR=0．92，95％CI[O．56，1．513）方面差异未见统计学意义。结论目前研究表明添加益生菌并不能够降低重症急性胰腺炎患者的感染率和死亡率，尚需大样本、高质量的随机对照试验以进一步明确。
Objective To explore the effect of probioties on patients with severe acute pancreatitis. Methods Randomized controlled trims of probiotics in patients with severe acute pancreatitis were searched in Coehrane Library （2010）, Medline （1966 to September 2010）, China Academic Literature Full-text Database, Chinese Science and Technology Journal Database and WanFang Database between 1966 and September 2010. Evaluation of literature quality and data extraction were independently completed by two researchers. Data were analyzed with RevMan4. 3 software. Results A total of 313 papers had been searched. After excluded duplicated and low-level paper, six articles were included in this study. The result showed that the infection rate （OR=0.88, 95%C1[0. 56,1. 38]） and mortality rate （OR=1.44, 95%CI [0. 78,2. 64]） of patients with severe acute pancreatitis in intervention group were not lower than control group, however the length of stay in hospital was shorter in intervention group than control group （WMD=- 4.69, 95 %CI[-7.73, -1. 65]）. There was no significant difference between intervention group and control group in systemic inflammatory response syndrome （OR = 1. 33,95 % CI[0. 63,2.83]）, multiple organ failure （OR=1. 50, 95%CI[0. 89,2. 52]） and transfering to surgery department for further treatment （OR= O. 92, 95%CI[0.56,1.51]）. Conclusion So far the studies indicated that probiotics could not lower the infection rate and mortality rate in patients with severe acute pancreatitis. Large sample and highquality randomized controlled trials are needed for further evaluation.
出处
《中华消化杂志》
CAS
CSCD
北大核心
2012年第2期93-97,共5页
Chinese Journal of Digestion
