摘要
目的评价异维A酸红霉素凝胶治疗轻、中度寻常痤疮的疗效及安全性。方法采用随机、开放、平行对照实验设计。人选200例患者，剔除3例，脱落24例，纳入安全性分析197例，疗效分析173例，治疗组87例给予异维A酸红霉素凝胶，对照组86例给予维A酸软膏，均每晚外用1次，疗程为8周，观察疗效及不良反应。结果治疗组与对照组有效率分别为64．37％（56／87）和58．14％（50／86），差异无统计学意义（P〉0．05）；不良反应发生率分别为15．31％和14．14％，差异无统计学意义（P〉0．05）。结论异维A酸红霉素凝胶治疗轻、中度寻常痤疮安全有效。
Objective To explore the clinical efficacy and safety of isotretinoin erythromycin gel in the treatment of mild to moderate acne vulgaris. Methods A randomized, open, parallel, con- trolled clinical study was conducted. A total of 200 patients were enrolled in this study, in which 3 pa- tients were excluded and 24 patients droped off during the study. Efficacy analysis was carried out in 197 patients and safety analysis in 173 patients. The patients were classified into trial group （n--87） and control group （n：86） to be treated with isotretinoin erythromycin gel or tretinoin cream once a night for 8 weeks, respectively. The clinical effects and adverse drug reactions were observed. Results The effective rates were 64.37 % （56/87） in trial group and 58.14 % （50/86） in control group with no statistical significance （P〉0.05）. The rate of adverse reactions were 15.31 G in trial group and 14.14 % in control group with no statistical significance （P〉0.05）. Conclusions Isotretinoin eryth- romycin gel is safe and effective in the treatment of mild to moderate ache vulgaris.
出处
《中华医学美学美容杂志》
2012年第1期37-39,共3页
Chinese Journal of Medical Aesthetics and Cosmetology
关键词
痤疮
寻常
异维酸
红霉素
Acne vulgaris
Isotretinoin
Erythromycin
