摘要
为了在脑电信号波形的特定相位处施加电刺激,利用NI公司的通用数据采集卡和LabVIEW虚拟仪器环境,开发了一种闭环式电刺激系统。采集卡的A/D通道采样大鼠大脑海马区的场电位信号,LabVIEW程序分析幅值和周期特性,预测即将到来的场电位θ节律的波峰或者波谷,并在指定相位处经由采集卡的数字口或者D/A通道输出所需的刺激信号,以实现闭环式刺激。实验结果表明,θ节律波峰和波谷的预测正确率分别达到92%和86%。该电刺激系统的通用性和灵活性使其能够用于多种神经节律波相位以及其他信号特征的预测,为神经电生理研究和大脑疾病的电刺激治疗提供了一种新型闭环控制刺激方法。
In order to exert electrical stimulation at a given phase of brain electric signal waveforms, a closed-loop system was developed using a general NI data acquisition card together with LabVIEW virtual instrument environ- ment. One of the A/D channels on the card is used to record the field potential signals from the hippocampal region in a rat brain. A customized LabVIEW program analyzes the amplitude and frequency features of the signals, and then predicts the upcoming peak or trough of the theta rhythms in the field potentials. Finally, stimulation waveforrns are outputted from a digital I/O port or a D/A channel of the card exactly at the expected time phase to realize the closed-loop stimulation. Experimental results show that the percent prediction accuracies are 92% and 86% for peak and trough predictions, respectively. The electrical stimulation system is versatile and flexible, and can be used for predicting various rhythm phases and other features appeared in neural signals. It provides a novel closed-loop con- trol method for neural stimulation both in neuroelectrophysiology researches and in electrical stimulation therapy of brain diseases.
出处
《仪器仪表学报》
EI
CAS
CSCD
北大核心
2012年第2期279-285,共7页
Chinese Journal of Scientific Instrument
基金
国家自然科学基金(30970753)资助项目
关键词
电刺激
闭环
神经系统
节律
场电位
electrical stimulation
closed-loop
neural system
rhythm
field potential
