摘要
奥沙利铂是第3代铂类抗癌药物,抗癌谱广、毒副反应轻微是其主要特点。但该药的外周神经毒性发生率却高达90%,是其剂量限制性毒性。现对奥沙利铂(乐沙定)神经毒性表现、分级、发生机制及防治策略进行综述,以便为奥沙利铂疗程持续和达到更好疗效、更小毒性提供依据。
Oxaliplatin is the third generation of the platinum,is effective in the treatment of multiple solid tumors and also quite safe.However,there is a high incidence of peripheral neurotoxiciy,which is dose-limiting.In this article,the clinical manifestations,mechanism of neurotoxicity and therapy are reviewed to provide evidence in the efficacy and the safety of oxaliplatin for the continuous treatment of this disease.
出处
《中国医药科学》
2012年第3期38-40,共3页
China Medicine And Pharmacy
基金
河南省医药卫生重大攻关项目
卫生部科研基金资助项目(WKJ2011010012)
