摘要
通过生物信息学软件开展了基于表位预测的番鸭细小病毒（MDPV）和鹅细小病毒（GPV）免疫交叉反应研究。番鸭细小病毒非结构蛋白线性抗原表位预测结果表明：AA248~252、503~509和545~554可能是线性表位优势区域,与已知的鹅细小病毒非结构蛋白线性抗原表位区进行比较,可能具有交叉反应性的区段为AA503~509。番鸭细小病毒衣壳蛋白线性抗原表位预测结果表明：肽段AA27~33、39~50、67~75、111~115、149~155、260~264、321~325、426~430、448~452、485~489、521~525、540~544和685~691等区域可能是线性表位优势区域,与已知的鹅细小病毒衣壳蛋白线性抗原表位区进行比较,可能具有交叉反应性的区段为AA321~325、426~430、540~544和685~691。
In order to explain cross-reactivity between Muscovy Duck Parvovirus（MDPV） and Goose Parvovirus（GPV）,DNAMAN and DNAStar were used for the epitope analysis.It indicated that the linear epitopes on MDPV non-structural protein existed with high probability in the regions of AA248~252,503~509 and 545~554.Comparing with definite linear epitopes on GPV non-structural protein there was only one epitope might cross-react with each other,it was AA503~509.It indicated that the linear epitopes on MDPV capsid protein existed in the regions of AA27~33,39~50,67~75,111~115,149~155,260~264,321~325,426~430,448~452,485~489,521~525,540~544 and 685~691.Comparing with definite linear epitopes on GPV capsid protein there were four epitopes might cross-react with each other,they were AA321~325,426~430,540~544 and 685~691.
出处
《广东农业科学》
CAS
CSCD
北大核心
2011年第24期120-121,共2页
Guangdong Agricultural Sciences
基金
齐齐哈尔大学青年教师科研启动项目(2010k-M08)
