摘要
目的观察口服降糖药血糖控制不佳的2型糖尿病患者，分别加用地特胰岛素（Det）或中性鱼精蛋白锌胰岛素（NPH）治疗的有效性、安全性及对体重的影响。方法将84例口服降糖药血糖控制不佳的2型糖尿病患者随机分为两组，分别睡前加用Det和NPH，治疗16周。结果治疗16周后，两组患者空腹血糖和糖化血红蛋白均较基线下降（P〈0．01），但两组间比较差异无统计学意义（P〉0．05）；Det组低血糖发生率为2．4％，较NPH组的9．5％更低，Det组体重增加明显低于NPH组（P〈0．01）。结论对于口服降糖药血糖控制不佳的2型糖尿病患者，加用Det与加用NPH相比，有效性相似，但体重增加少，低血糖发生率低，安全性更高。
Objective To compare the efficacy,safety and effect on weight between once-daily detemir and NPH in poorly controlled type 2 diabetes with oral antidiabetic drugs. Methods 84 type 2 diabetic patients were randomized to two groups of receiving insulin detemir or NPH for 16 weeks. The pa- rameters measured included FPG, HbAlc and weight. Hypoglycemia was also noted. Results FPG and HbAlc were both significantly decreased than before （P 〈 0.01 ）, but there was no statistical difference between two groups（ P 〉 0.05 ）. Comparing NPH group ,the increased weight was less. in detemir group（ P 〈 0.01 ）. The incidence of hypoglycemia was 2.4% in insulin detemir group, and 9.5% in insulin NPH group,the incidence of hypoglycemia in insulin detemir group was less than that in insulin NPH group（P 〈 0.01）. Conclusion The efficacy was similar between NPH and detemir groups inpoorly controlled type 2 diabetes patients,and detemir was better on safety and weight gain than NPH.
出处
《临床内科杂志》
CAS
2012年第1期43-45,共3页
Journal of Clinical Internal Medicine
