摘要
目的探讨δ-catenin、Ki-67在非小细胞肺癌中的表达状况及其与临床病理学参数间的关系。方法利用免疫组织化学(ElivisionTM plus法),检测肺癌组织芯片中155例非小细胞肺癌患者δ-catenin、Ki-67的表达情况。结果肺癌组织的δ-catenin蛋白阳性表达率为61.30%(95/155),相应癌旁组织δ-catenin阳性表达率为35.6%(16/45),差别有显著意义(<0.05)。δ-catenin在TNM III/IV期的NSCLC组织中阳性表达率为73.2%(41/56),明显高于在Ⅰ/II期NSCLC组织中阳性表达率54.5%(54/99,=0.022);δ-catenin在出现淋巴结转移的表达率为72.3%(60/83),显著高于没有淋巴结转移的阳性表达率48.6%(35/72,=0.003);非小细胞肺癌中δ-catenin高表达同Ki-67高表达呈显著正相关关系(χ2=12.685,r=0.282,<0.01)。结论δ-catenin的高表达与非小细胞肺癌的分期,淋巴结转移及增殖有关。
Objective To explore the expression and significance of δ-catenin,Ki-67 in non-small-cell lung cancer（NSCLC）.Methods The expressions of δ-catenin and Ki-67 in 155 specimens of lung cancer were detected by immunohistochemistry in tissue microassay.Results The overexpression of δ-catenin was detected in 95（61.30%） of the 155 human lung cancer tissues,and significantly higher than that in normal lung tissues（35.6%）.The positive expression of δ-catenin was higher in advanced TNM stages（III＋IV） of NSCLC,compared to lower stages（I＋II）（=0.022）.A correlation between δ-catenin expression and lymph node metastasis was found in our study（=0.003）.Besides,we also found that the overexpression of δ-catenin was positively correlated with Ki-67 in NSCLC（χ2=12.685,r=0.282,0.01）.Conclusion The overexpression of δ-catenin is correlated with advanced pTNM stage,lymph nodal metastasis and proliferative ability of NSCLC.
出处
《解剖科学进展》
CAS
2012年第1期79-82,共4页
Progress of Anatomical Sciences
基金
国家自然科学基金资助项目(No.81071717)
