摘要
MicroRNAs(miRNAs)是近年来发现的一种重要的内源性非编码小RNA(20～25个碱基),在进化上高度保守,广泛参与细胞增殖、分化、凋亡、代谢、激素分泌及个体发育等生物学过程。随着对miRNA的深入研究,其独特的生物学功能及调控机制在学术界引起了广泛关注,包括在心脑血管疾病方面。近期研究表明,特定miRNA在缺血性脑血管疾病,如脑卒中的发生与发展过程中发挥着重要作用,并参与了脑损伤后的保护和修复机制的调控。本文重点概述了脑卒中后特定miRNA与血管新生、炎症反应以及神经发生的关系,为miRNA在临床上治疗缺血性脑卒中提供诊断和预测的依据和思路。
MicroRNAs（miRNAs） are important small noncoding endogenous RNAs（20-25 nucleotides in length） which were discovered not long ago but have been placed with significant amount of research efforts in recent years.,MiRNAs are evolutionarily highly conserved,and regulate a wide range of biological processes including ontogenesis,apoptosis,proliferation,differnetiation,metabolism,hormone secretion and so forth.With the progress in the studies of miRNAs,their unique biological functions and regulatory mechanism have been revealed.It has been demonstrated that certain miRNAs play an important role in the occurrence and development of ischemic cerebrovascular diseases,such as stroke.In addition,these miRNAs also participate in the regulation of the post-injury protection and repair.Herein we summarize the relationship between some identified miRNAs and angiogenesis,inflammation and neurogenesis during and after stroke.It is hoped that such knowledge would provide us with some hints for the diagnosis,prediction and clinical treatment of ischemic stroke.
出处
《分子诊断与治疗杂志》
2012年第1期1-10,共10页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金(30900756)
上海市科委青年启明星计划(09QA1403400)
上海交通大学医工交叉面上项目(YG2009MS55)
教育部留学回国人员科研启动基金(K10MD06)
