摘要
热熔挤出技术主要用于提高难溶性药物的溶出度及其生物利用度,具有工艺简单、连续化操作、生产效率高和在线监测等优点,已成为国外制备固体分散体的主导技术,显示出独特的优势和应用潜力,近年来受到药学工作者的广泛关注。本文综述了热熔挤出技术制备固体分散体的优势、工艺研究、载体材料和质量评价等研究成果,旨在为热熔挤出技术制备固体分散体的推广和应用提供参考和依据。
Hot-melt extrusion （HME） is mainly used to enhance the dissolution rate and bioavailability of poorly water soluble drugs. It has many advantages, such as simple process, continuous operation, high efficiency, on-line monitoring and so on. HME provides an innovative approach, which has been concerned by pharmaceutical workers, for preparation of solid dispersion abroad. This article reviews recent advances on preparation of solid dispersion by HME in preparation processing, carrier materials and quality evaluation in order to further promote and apply HME in preparation of solid dispersion.
出处
《药学学报》
CAS
CSCD
北大核心
2012年第2期163-167,共5页
Acta Pharmaceutica Sinica
基金
澳门大学研究基金资助项目(MYRG208(Y1-L4)-ICMS11-WYT)
关键词
热熔挤出技术
固体分散体
载体材料
质量评价
hot-melt extrusion
solid dispersion
cartier material
quality evaluation
