摘要
目的探讨中原地区妇女宫颈癌患者人乳头瘤状病毒(human papillomav irus,HPV)感染分布情况及主要型别。方法采用人乳头瘤病毒核酸扩增分型检测试剂盒,对80例中原地区妇女经病理确诊宫颈癌患者的宫颈脱落细胞进行HPV基因分型检测。结果 80例宫颈癌患者中有76例HPV阳性,阳性率为95.0%,其中HPV16感染率最高为53.9%,其他高危型的感染率从高到低依次为HPV16、52、58、33、18、31、56、68、59、39、45、35、51。低危型中HPV11型感染率最高为10.5%,其他低危型的感染率从高到低依次为HPV6、44、42、43。多重感染率为25.0%。正常对照组65例中有15例HPV阳性(23.1%),HPV16感染率最高为26.7%。宫颈癌HPV阳性率明显高于正常对照组,差异有统计学意义(P<0.05)。结论中原地区妇女宫颈癌患者中以HPV16、52、58、33感染为主要型别,可能是中原地区妇女宫颈癌较易感染的型别。
Objective To detect the distribution of human papillomavirus (HPV) infection and the major types of patients with cervical cancer in Zhongyuan areas.Methods 80 patients in Zhongyuan areas with cervical cancer conducted in this study HPV genotype was detected by human papillomavirus PCR types diagnos tickit.Results 76 patients among the 80 cases were HPV positive with the positive rate 95.0%,of which,HPV16 was the most common subtype(53.9%).Other high risk types were HPV16、52、58、33、18、31、56、68、59、39、45、35、51。The most common infectio nrate of low risk type was HPV11(10.5%).The infection rates of other low risk ty pes were HPV6、44、42、43.The multiple infection rate was 25%.15 patients of the 65 normal women (control gr oup) were HPV positive (23.1%),and among them the highest infection rate of HPV16 was 26.7%.The positive HPV rate of cervical cancer group was significantly higher than that of control group (P<0.05).Conclusion The major subtypes of HPV in Zhongyuan areas patients with cervical cancer were type 16, 52, 58 and type 33.
出处
《中国医学创新》
CAS
2012年第2期83-85,共3页
Medical Innovation of China
基金
郑州市科研项目(2010SFXM224)
