摘要
目的 对视网膜自适应光学成像系统所得视锥细胞图像进行处理,获取正常人眼底不同区域视锥细胞密度,探讨自适应光学成像系统用于眼科临床实验研究的可行性.方法 横断面研究.利用自适应光学成像系统采集30例正常受试者不同区域视锥细胞图像,对图像进行处理获得正常人眼视网膜不同区域的视锥细胞密度,并采用回归分析法对不同区域的密度进行曲线估计.结果 随测量点与黄斑中心凹的距离增加,视锥细胞密度呈现出降低的趋势.偏离黄斑中心凹0.5°到3°范围内,随着偏离度的增加,视锥细胞密度从70 000个/mm2下降到16 000个/mm2.结论 自适应光学成像系统能够在活体人眼获取清晰的高分辨率视网膜图像,可能可以在眼科临床实验研究中发挥一定的作用.
Objective To study a practical application in clinical ophthalmology studies by measuring cone photoreceptor density from processed images obtained with an adaptive optics imaging system.Methods This was a cross-sectional study.An adaptive optics imaging system was used to image the cones of 30 normal human eyes and the position of each cone within the sampling windows was manually digitized by the investigator.From these cone counts,the density of the cones was calculated for a set of fixed distances from the fovea at locations throughout the image,and the images were processed to obtain the cone photoreceptor density in different regions （nasal and temporal sides, superior and inferior sides）.A regression analysis was used to estimate the cone photoreceptor density in different regions. Results Cone photoreceptor densities decreased from 70 000 cells/mm2 to 16 000 cells/mm2 from a retinal eccentricity of 0.5°to 3°.Overall, cell densities showed a tendency to decrease with deviation from the fovea. Conclusion Clear high-resolution retinal images from human eyes in vivo can be obtained with an adaptive optics imaging system.This system may play a role in ophthalmology based clinical trials.
出处
《中华眼视光学与视觉科学杂志》
CAS
2011年第6期419-422,共4页
Chinese Journal Of Optometry Ophthalmology And Visual Science
基金
国家863计划资助项目（2007AA04Z324）
重庆市攻关计划资助项目（CSTC,2010AB5118）
