摘要
目的了解喹诺酮类药物在临床应用中不良反应发生的种类和相关原因,为减少喹诺酮类药物应用中的不良反应提供指导。方法对150例喹诺酮类药物治疗后出现不良反应患者的用药情况和不良反应进行监测,并详细记录和统计分析。结果从给药途径来看,静脉给药125例,占83.3%,口服给药25例,占16.7%,静脉给药的比例远远高于口服给药;在6个喹诺酮类药物中,加替沙星引起的不良反应例次最多,达69例,占46.0%,其次为氟罗沙星25例,占16.7%;不良反应中表现为轻度者120例,中度者20例,重度者10例,分别占80.0%、13.3%、6.7%。结论喹诺酮类药物在临床应用中的不良反应表现多样,多由静脉给药和加替沙星造成,主要以变态反应和神经系统异常反应多见,多呈现轻度反应,经综合治疗后预后较好。
Objective To investigate types and causes of adverse reaction of quinolones in clinical application so as to provide the basis for reducing the reaction. Methods One hundred and fifty patients with adverse reaction after treatment with quinolones were monitored with detailed record and statistical analysis. Results In terms of medication, 125 （ 83. 3 % ） were inj ected intravenously, far more than those administered orally（ 25,16. 7 % ） ; among 6 quinolones,galtixacin resulted in adverse reactions most frequently（66,46. 0%）,next was fleroxacin（25,16. 7%）. In all the adverse reactions, 120 （80. 0 % ） were mild, 20 （ 13. 3 % ） moderate and 10 （ 6. 7 % ） severe. Conclusion Adverse reaction to quinolones may differ greatly in clinical application, which often results from intravenous injection and galtixacin. Allergic reaction and abnormal nervous system reaction are common in these reactions. And most adverse reactions are mild so patients often have good prognosis through comprehensive treatment.
出处
《成都医学院学报》
CAS
2011年第4期354-355,共2页
Journal of Chengdu Medical College
关键词
喹诺酮类药物
不良反应
静脉给药
变态反应
加替沙星
Quinolones
Adverse Reaction
Intravenous in] ection
Allergic Reaction
Galtixacin
