摘要
目的探讨精神分裂症疾病自身和患者一般情况等对骨密度及骨质疏松发生率的影响及相关性。方法 :检测163例精神分裂症患者住院1年时的骨密度及其中65例住院3年时的骨密度,与90例健康体检者进行比较。结果 :精神分裂症患者骨密度显著低于健康对照者(t=-5.530～-3.599,P<0.01),同时骨质疏松的发生率亦显著增高(χ2=18.793～31.199,P<0.01)。住院3年与住院1年的精神分裂症患者的骨密度值(t=-0.351～0.297,P>0.05)及骨质疏松发生率比较未见显著差异(χ2=0.381～0.012,P>0.05)。精神分裂症不同分型间骨质疏松的发生率存在差别,尤以未定型较高(χ2=10.506～15.442,P<0.05)。体重是精神分裂症患者骨密度的重要影响因素(r=0.307～0.400,P<0.01)。结论 :精神分裂症疾病自身可能对患者骨代谢紊乱有重要作用。精神分裂症患者骨密度较普通人群明显偏低,骨质疏松发生率偏高。
Objective To explore the effect and relevance of schizophrenia and general status of patients on bone mineral density （BMD） and incidence of osteoporosis. Methods BMD was measured in 163 schizophrenia patients at 1 year in hospital and in 65 patients at 3 years in hospital and was compared with BMD of 90 healthy volunteers. Results BMD of schizophrenic patients was significantly lower than healthy controls （t = - 5. 530-3. 832, P 〈 0. 01 ） , and the incidence of osteoporosis significantly increased （X2 = 18. 793-31. 199, P 〈 0. 01 ）. The differences of BMD and incidence of osteoporosis between 1 year and 3 years in hospital were not statistically significant （t = 0. 351-0. 297, P 〉 0. 05 ; X2 = 0. 381-2. 164, P 〉 0.05）. The incidence of osteoporosis among different sub-types of schizophrenia was significantly different. It was highest in undifferentiated schizophrenia （X2 = 10. 506-15. 442, P 〈 0. 05）. Body weight was an important risk factor for BMD in patients with schizophrenia （r = 0. 307-0. 400, P 〈 0.01 ）. Conclusion Schizophrenia alone may have an important role in bone metabolic disorders. Bone mineral density in patients with schizophrenia is significantly lower than in general population, and the incidence of osteoporosis is much higher.
出处
《中国骨质疏松杂志》
CAS
CSCD
2011年第12期1073-1076,共4页
Chinese Journal of Osteoporosis
基金
山东省医药卫生科技发展计划项目(2007HZ08)
关键词
精神分裂症
骨密度
骨质疏松
Schizophrenia
Bone mineral density
Osteoporosis
