摘要
随着诊疗手段的日益进步,炎症性肠病(inflam matory bowel disease,IBD)发病率近年来呈逐年上升趋势.然而由于临床表现复杂多样,不仅有消化道症状,还可有肠外表现,并且缺乏特异性指标,IBD诊断容易误诊,且评估疾病活动性也较困难.放射学,内镜及组织学活检都为诊断及评估提供了方法,但这些方法受射线、有创性、昂贵等缺点限制.目前临床上需要一种简单、无创、敏感、经济、特异性强、在临床上易推广的方法来应用于对IBD的诊断及活动性的判定,因此生物活性标志物被大量研究.本文从鉴别溃疡性结肠炎(ulcerative colitis)和克罗恩病(Crohn's disease)及反应炎症的存在或程度两方面就临床有适用性的生物学活性标志物的研究进行了综述.
The incidence of inflammatory bowel disease（IBD） has been increasing in recent years.The clinical manifestations of IBD are complicated,and both intestinal and extraintestinal symptoms may develop.Due to the lack of specific index,IBD is easy to be misdiagnosed,and evaluating disease activity is more difficult.Radiology,endoscopic and histological biopsy for diagnosis are expensive.Currently,there is an urgent need of a simple,noninvasive,sensitive,economic,and highly specific method for diagnosis of IBD.Biological activity markers may meet this demand. In this paper,the clinical applicability of biological activity markers,which come from both ulcerative colitis（UC） and Crohn＇s disease（CD） ,in identifying the presence or extent of inflammatory response,is reviewed.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第31期3229-3236,共8页
World Chinese Journal of Digestology
关键词
炎症性肠病
生物活性标志物
克罗恩病
Inflammatory bowel disease
Biological activity markers
Crohn＇s disease
