摘要
目的探讨美沙拉嗪缓释颗粒对溃疡性结肠炎患者的疗效,以及对血清白介素(IL-6)、肿瘤坏死因子(TNF-α)影响机制的研究。方法入院确诊的70例溃疡性结肠炎患者随机分为治疗组(美沙拉嗪缓释颗粒)和对照组(SASP)各35例,比较两组治疗前后肠镜变化、临床疗效及血清IL-6、TNF-α的变化情况。结果治疗组的疗效优于对照组(P<0.01)。两组治疗后的IL-6、TNF-α较治疗前明显降低,P<0.01t,值分别为12.36,12.75,12.24,12.42,且治疗组的降低程度较对照组更明显,差异有统计学意义t,值分别为12.27,12.35,P<0.01。结论美沙拉嗪缓释颗粒治疗溃疡性结肠炎可显著提高临床疗效,考虑可能是通过降低IL-6水平、TNF-α而起作用的,其具体机制尚有待进一步研究。
Objective To investigate the efficacy of mesalazine on the of ulcerative colitis,and to explore the mechanism of serum interleukin （IL-6）, tumor necrosis factor （TNF-α） in UC. Methods All of 70 patients with ulcerative colitis were randomly divided into treatment groups （mesalazine slow-release granules） and the control group （SASP） two groups,each 35 cases,endoscopic changes and clinical efficacy and serum IL-6,TNF-α changes were compared before and after treatment. Results The efficacy of the treatment group was better than the control group （P〈0.01）. After treatment, the levels of IL-6 was significantly lower than before treatment,the treatment group decreased level of serum IL-6 was more significantly than the control group, the difference was statistically significant,P〈0.01. Conclusion Mesalazine slowes release granules for ulcerative colitis,and it can significantly improve the clinical efficacy,consideration may be by reducing the level of IL-6 play a role,the specific mechanism remains to be further studied.
出处
《中国现代医生》
2011年第36期34-35,共2页
China Modern Doctor
