摘要
目的评估原发性肝癌介入术后完全缓解病灶磁共振表观扩散系数(ADC)值测量的可重复性和一致性,为临床应用提供参考。方法对21个完全缓解病灶在术后第1、3、6个月时由同一名医师同一序列测量ADC值、不同医师间隔1周测量病灶的ADC值,通过计算组内相关系数(ICC)值及绘制Bland-Altman图表确定ADC值测量的可重复性及一致性。ICC值大于0.75表示信度良好,可重复性高,75%的位点位于Bland-Altman图95%的置信区间的参考线内,其一致性高。结果 A医师术后1、3、6个月测量ICC值分别为0.928、0.878、0.934;B医师术后1、3、6个月测量ICC值分别为0.873、0.940、0.871,1周前不同时间A、B医师1、3、6个月测量ICC值分别为0.854、0.940、0.960;1周后不同时间A、B医师术后1、3、6个月测量ICC值分别为:0.788、0.945、0.858,均大于0.75,提示可信度较高,可重复性强。90%的位点Bland-Altman图95%的置信区间的参考线内,数值测量的可重复性高。结论 HCC完全缓解病灶的ADC值稳定,测量具有较高的一致性和可重复性,可以动态观察原发性肝癌介入治疗后病灶的稳定程度,可及时有效的评估巩固治疗时机。
Objective To assess the repeatability and consistency of magnetic resonance apparent diffusion coefficient（MR ADC） values of the completely remitted lesions of primary hepatocellular carcinoma（HCC） after TACE in order to provide a reference for clinical application.Methods The MR ADC values of 21 completely remitted lesions were measured at 1,3 and 6 months after TACE by the same radiologist（radiologist A） using the same sequence,which were measured again by another radiologist（radiologist B） one week later.By calculating the intra-class correlation coefficient（ICC） value and drawing Bland-Altman graph,the repeatability and consistency of the ADC value measurement were evaluated.ICC values 0.75 indicated good reliability and high repeatability.The consistency was considered to be enough high when 75% of the sites were located in the 95% confidence interval within the reference line on the Bland-Altman graph.Results The ICC values measured by radiologist A 1,3 and 6 months after TACE were 0.928,0.878 and 0.934 respectively,which were 0.873,0.940 and 0.871 respectively measured by radiologist B.The ICC values measured by radiologist A and radiologist B at different time one week before 1,3 and 6 months after TACE were 0.854,0.940 and 0.960 respectively,while the values were 0.788,0.945 and 0.858 respectively one week after 1,3 and 6 months after TACE.All the above values were greater than 0.75,indicating that the reliability was high.As 90% of the sites were located in the 95% confidence interval within the reference line on the Bland-Altman graph,the repeatability was regarded to be very high.Conclusion The ADC values of the completely remitted lesions of HCC after TACE are quite stable.The measurements of ADC values for these lesions carry high degree of repeatability and consistency.With the help of ADC values,the stability of HCC lesions after TACE can be dynamically assessed and the therapeutic effectiveness can be promptly evaluated.
出处
《介入放射学杂志》
CSCD
北大核心
2011年第11期867-871,共5页
Journal of Interventional Radiology
关键词
肝肿瘤
表观扩散系数
介入治疗
重复性
一致性
hepatic neoplasms
apparent diffusion coefficient
interventional treatment
repeatability
consistency
