摘要
目的评估戈舍瑞林对绝经前乳腺癌患者辅助化疗期间卵巢功能的保护作用。方法回顾性分析2年内收治的绝经前乳腺癌患者的临床资料,分成研究组(常规化疗+戈舍瑞林)和对照组(常规化疗),每组40例。观察两组患者月经情况及化疗期间与化疗结束后随访1年内的激素水平变化。结果 80例患者均完成化疗,化疗期间均出现月经周期紊乱。研究组和对照组月经恢复率分别为85%和55%,差异有统计学意义(P=0.007)。研究组在戈舍瑞林联合化疗期间,雌二醇(E2)水平减低到绝经后水平,促卵泡生成素(FSH)和促黄体生成素(LH)也明显降低;对照组在化疗期间E2水平逐渐降低,FSH和LH则明显增加。结论乳腺癌患者化疗期间应用戈舍瑞林,能有效地防止化疗引起的卵巢功能损伤,使大多数中青年患者维持正常月经及生育能力。
Objective To assess the protective effect of goserelin on the ovarian function of premenopausal patients with breast cancer during chemotherapy. Methods The clinical data of premenopausal patients with breast cancer treated in the recent two-year period were retrospectively analyzed. The patients were divided into study group （goserelin plus conventional chemotherapy ） and control group （conventional chemotherapy ） with 40 cases in each group. The menstrual status and the hormone levels during chemotherapy and first year follow-up after chemotherapy between the two groups were observed. Results All the 80 patients completed their chemotherapy treatment and all of them developed menstrual disorders. The menstrual recovery rate of the observation group and the control group was 85 % and 55 % , respectively, and the difference between the two groups had statistical significance （P = 0. 007 ）. In the observation group, the serum oestradiol （E2） decreased to postmenopausal level, and the serum levels of follicle stimulating hormone （ FSH ） were also significantly decreased during combination treatment （goserelin plus conventional chemotherapy ）. In the control group, the E2 levels decreased gradually while FSH and LH level increased significantly during chemotherapy. Conclusions Goserelin administration during chemotherapy can effectively prevent the ovarian function injury caused by chemotherapy, and can help maintain normal menstruation and fertility for the young and middle-aged patients.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2011年第11期1188-1191,共4页
China Journal of General Surgery
关键词
乳腺肿瘤
戈舍瑞林
卵巢功能
化学疗法
辅助
Breast Neoplasms
Goserelin
Ovary Function
Chemotherapy, Adjuvant
