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泌乳素诱导蛋白基因及其在肿瘤中作用的研究进展 被引量：1

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摘要 泌乳素诱导蛋白（prolactin inducible protein,PIP）是存在于人精液中17 kD的多肽[1].因其在不同部位被发现而有多种名称,在受泌乳素和雌激素调控的人乳腺癌细胞系T47D中被发现,而被称作PIP[1- 2];在乳腺囊液、人乳和唾液中被发现而被称为gross cystic disease fluid protein 15（GCDFP-15）[3];作为17 kD类肌动蛋白结合蛋白在人精液中被发现,而被命名为分泌性肌动蛋白结合蛋白（secretory actin binding protein,SABP）,也称作gp17[4];因其来源于下颌下腺和舌下腺的唾液而被称作腮腺外糖蛋白（extraparotid glycoprotein,EP-GP）[5].目前,GCDFP-15、PIP、SABP、gp17、EP-GP在基因术语中被统一称作PIP,人PIP基因位于7号染色体[6].PIP虽是一种小蛋白,但却在抗菌、受精、免疫调节、细胞凋亡及肿瘤进程中发挥着重要的生物学作用.本文着重对PIP基因及其在肿瘤中作用的相关研究进展进行综述.
作者 王素云 田炜
机构地区 河北联合大学医学实验研究中心
出处 《广东医学》 CAS CSCD 北大核心 2011年第21期2872-2874,共3页 Guangdong Medical Journal
关键词 蛋白基因 泌乳素 肿瘤 protein 人乳腺癌细胞系 GCDFP-15 结合蛋白 肌动蛋白
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献29

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同被引文献11

  • 1潘寿华,阎家峻,郑专.前列腺癌雄激素依赖转化后雄激素受体基因表达变化的研究[J].中国癌症杂志,2011,21(4):287-289. 被引量：3
  • 2田炜,郝志梅,梅津和夫,大泽资树.法医尸检样例中前列腺腺癌的发生率和分级[J].中国煤炭工业医学杂志,2007,10(5):614-615. 被引量：1
  • 3Hassan MI, Waheed A, Yadav S, et al. Prolactin inducible protein in cancer, fertility and immunoregulation: structure, function and its clinical implications [J]. Cell Mol Life Sci, 2009, 66 (3): 447- 459.
  • 4Takeda Y, Tsuta K, Shibuki Y, et al. Analysis of expression patterns of breast cancer-specific markers (mammaglobin and gross cystic disease fluid protein 15) in lung and pleural tumors [J]. Arch Pathol Lab .Med,2008,132(2): 239-243.
  • 5Tian W, Osawa M, Horiuchi H, et al. Expression of the prolactin- inducible protein (PIP/GCDFP15) gene in benign epithelium and adenocarcinoma of the prostate [J]. Cancer Sci, 2004, 95(6): 491- 495.
  • 6Blanchard A, Nistor A, Castaneda FE, et al. Generation and initial characterization of the pro lactin-inducible protein (PIP) null mouse: accompanying global changes in gene expression in the submandibular gland [J]. Can J Physiol Pharmacol, 2009, 87(10): 859-872.
  • 7Culig Z, Hoffmann J, Erdel M, et al. Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumor progression in a new model system [J]. Br J Cancer, 1999, 81(2): 242-251.
  • 8Hassan MI, Bilgrami S, Kumar V, et al. Crystal structure of the novel complex formed between zinc alpha2-glycopmtein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma[J]. J Mol Biol,2008,384(3): 663-672.
  • 9Fujimoto N, Ych S, Kang HY, et al. Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate [J]. J Biol Chem, 1999, 274(12): 8316-8321.
  • 10Agoulnik IU, Weigel NL. Androgen receptor action in hormone- dependent and recurrent prostate cancer [J]. J Cell Biochem, 2006, 99(2): 362-372.

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广东医学
2011年 第21期

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