摘要
雄性小白鼠隔日皮下注射D-半乳糖40mg/kg68天可造成亚急性衰老模型,在注射D-半乳糖的同时PO淫羊藿黄酮0.70g/kg能显著恢复D-半乳糖衰老模型小鼠T和B淋巴细胞增殖反应的功能,明显提高小鼠肝脏总SOD的活性,减少肝组织过氧化脂质的形成,减少心、肝等组织的脂褐素形成,但对脑的脂褐素减少不明显。
This paper reports the evaluation on the antiaging effects of flavonoids of epimedium koreanum (TF) in D-galactose-injected mice. The animals were divided into three groups: (1) Control group were injected with NS 0.2ml/mouse. SC on every two days for 68 days.(2) Aged model group were injected with D-galactose 40mg/kg SC at intervals of two days. (3) The medication group: D-galactose (SC) and TF (PO) were given at the same time for 68 days. It was shonw that the founetions of the T and B cell proliferation response were significantly regained, the activity of sueroxide dismutase in liver was markedly increased and the lipid peroxide level of liver tissue and the lipofuscin of heart and liver tissue were obviously reduced by given TF at the dose of 0.7g/kg on every two days (P<0.01 VS aged model group). These results suggest that TF appear to be a useful autiaging medicine.
出处
《中药药理与临床》
CAS
CSCD
1990年第2期18-20,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
淫羊藿黄酮
D-半乳糖
衰老
flavoaoids of epimedium koreanum D-galactose aging
