摘要
１９８８年４月至１９９０年４月对８５例食管鳞癌进行常规分割和后程加速超分割放疗随机前瞻研究。常规分割组４２例，每周￣６０Ｃｏ放射５次，每次１．８Ｇｙ，总疗程７．６周照射６８．４Ｇｙ。后程加速超分割组４３例，放射前程为常规分割，每次１．８Ｇｙ。４．６周照射２３次共４１．４Ｇｙ，然后缩野，每周照射５天，每天２次，每次１．５Ｇｙ，间隔４小时以上，１．８周照射１８次共２７Ｇｙ，总疗程６．４周，总剂量６８．４Ｇｙ。后程加速超分割放疗组１、２、３年食管局部病灶控制率和生存率分别为６９．０％，６１．９％，５９．５％和７２．１％，５５．８％，４１．９％。常规分割组分别为３９．０％，３１．７％，２９．３％和４７．６的，２６．２％，１９．０％。后程加速超分割放疗组的局部控制率和生存率明显高于常规分割放疗组。
AbstractFrom April 1988 to April 1990,85 patients with esophageal squamous cell carcinoma wererandomized into two groups:convontional fractionation (CF)and late course acceleratedfractionation(LCAF) radiothcrapy groups. 42 paticnts were treatcd with daily fractions of 1.8Gy,5day/week to the total dose of 68.4Gy/38 fx/7.8wks in CF group.43 patients wt3re treated by thesame fractions as CF group to the total dose of 41.4Gy/23k/4.5wks, and then followed byaccelerated fractionation radiotherapy with smaller fields,twice daily of 1.5Gy, with a minimuminterval of 4 hours betwcen fractions to the total dosc of 68.4Gy/41 fx/6.4wks in LCAF group. The1-, 2- and 3year local control and survival rates were 69%,61.9%, 59.5%and 72.1%, 55.8%, 41.9%in LCAF group and were 39%,31.7%,29.3% and 47.6%, 26.2%, 19%in CF group, respectively. Thelocal control and survival rates in LC A F group were significantly higher than in CF group.
出处
《中华放射肿瘤学杂志》
CSCD
1994年第3期150-153,216,共5页
Chinese Journal of Radiation Oncology
