摘要
应用病例对照的研究方法探求胆囊癌和胆囊结石的关系。43例胆囊癌,伴胆囊结石19例,无结石24例。对照组为B超检查88例中,发现胆囊结石6例、无结石82例。差异有非常显著性(P<0.0001)。有结石对于无结石病人患胆囊癌的相对危险度(RR)=10.8;95％可信区间(CI):3.9～30.1。同时收集国内文献中,胆囊癌1180例,合并胆囊结石565例,文献对照组,普查105019例,发现胆石病7023例,P<0.0001;RR=12.8;95％CI=11.4～14.4。胆囊结石病人患胆囊癌的相对危险度是无胆囊结石病人的10倍左右(10.8～12.8)。
A case-control study was performed to investigate the relationship between gallbladder cancer(GCA) and gallbladder stones (GS). 43 patients with GCA confirmed by pathology were included, in which 19 were accompanied by GS, 24 patients without. 88 controls were selected from the data for the periodic health checkup with B-ultrasonography(B-US): cholelithiasis were discovered in 6 controls, but 82 were free from GS. The difference between the case and control group was significant(P<0.0001). There was a strong relationship between GCA and GS with a relative risk(RR) of 10.8 and 95% confidence interval (CI)=3.9-30.1. Moreover, from the medical literature published in China, 1180 cases with GCA were collected, in which there were 565 patients with GS; 105 019 subjects were screened for cholelithiasis with B-US, in which 7023 gallstone diseases were identified. The difference between these two groups was significant(P<0.0001),a strong relationship between GCA and GS was also found with a RR of 12.82 and 95% CI=11.4-14.4. It revealed that the RR for GCA in gallbladder stone patients was about ten times that in non-GS individuals.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1996年第S1期95-97,共3页
Chinese Journal of Digestion
关键词
胆囊癌
胆囊结石
相对危险度
病例对照研究
Gallbladder cancer Cholelithiasis Relative risk Case-control study
