摘要
为探讨肾移植术后采用三联药物治疗出现硫唑嘌呤（Aza）毒性反应情况，分析了1985年以后施行肾移植而出现Aza毒性反应43例。所有患者均采用环孢素A、Aza和尼松联合治疗，结果28例发生肝功能损害，15例发生白细胞减少（＜3×109／L）。28例肝功能损害者中，单纯Aza肝中毒6例（21．4％），伴环孢素A血浓度升高9例（32．1％），伴肝炎标志物阳性12例（42．9％）。认为Aza所致肝功能损害发生率较高，为71．4％，值得注意；对有严重Aza毒性反应者，推荐用环磷酰胺来替代。
Aza toxic reactions were studied in 280 renal transplantation recipients treated by CSA combined with Aza and Pred from 1985 to 1994. It was found that the liver function impair ment occurred in 28 cases and the decrease of leukocyte count (<3×109/L) in 15 cases. Of the pa tients with liver function impairment, 6 cases (21.4%) were caused by Aza alone, 9 cases (32. 1%) were accompanied by the increased blood CSA concentration and 12 cases (42. 9%) were accompa nied by positive antigen or antibody of hepatitis. 20 cases (71. 4%) were related to Aza toxicity.The results showed that Aza toxic reacfion,especially the incidence of hepatotoxicity was higher. It is recommended that Aza should be replaced by CTX in the treatment of the patient with severe Aza toxic reaction.
出处
《临床泌尿外科杂志》
1998年第3期103-105,共3页
Journal of Clinical Urology
关键词
硫唑嘌呤
毒性反应
肾移植
Aza Toxic reaction Renal transplantation
