摘要
目的 研究 1949～ 1998年用氨苯砜单疗或联合化疗后麻风患者的复发趋势和特点。方法应用电脑对收集自中国 1949～ 1998年的麻风复发个案资料进行分析。结果 1949～ 1998年间累计复发患者 12 403例，累计复发率为 3.28％。其中氨苯砜单疗复发 11 803例，复发率为 3.83％。联合化疗复发 236例，复发率为 0.57％。经治少菌型麻风联合化疗半年的复发率（ 0.84％）显著高于初治少菌型麻风联合化疗半年的复发率（ 0.36％）。经治多菌型麻风联合化疗 2年的复发率（ 0.37％）也显著高于初治多菌型麻风联合化疗 2年的复发率（ 0.23％）。复发患者Ⅱ 级畸残率及细菌的阳性率分别为 49.9％和 69.3％。结论 氨苯砜单疗复发高峰出现于 1959～ 1988年间，联合化疗复发出现于 80年代末，并在未来的 10～ 20年可能达高峰。
Objective To study clinical characteristics and the trends of leprosy relapse cases after dapsone(DDS) monotherapy or multidrug therapy(MDT) from 1949 to 1998. Methods The data of leprosy relapse cases in China from 1949 to 1998 were analyzed. Results There were a total of 12 403 leprosy relapse cases during 1949～ 1998 in China with a cumulative relapse rate of 3.28％ . Among them, 11 803 were relapsed after DDS monotherapy with a relapse rate of 3.83％ and 236 were after MDT with a relapse rate of 0.57％ . The relapse rate (0.84％ ) in PB cases which were previously treated with DDS monotherapy a half year was significantly higher than that (0.36％ ) in PB cases treated with MDT a half year. The relapse rate (0.37％ ) in MB cases which were previously treated with DDS monotherapy plus MDT also significantly higher than that (0.23％ ) in MB cases which were just treated with MDT two years. The proportions of cases with gradeⅡ disabilities and positive skin smears in relapse cases were 49.9％ and 69.3％ , respectively. Conclusion The peak of leprosy relapses after DDS monotherapy occurred during 1959～ 1988. The relapses after MDT started at the end of 1980s and may reach its peak in the next decades.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2000年第S1期10-13,共4页
Chinese Journal of Dermatology
关键词
麻风
复发
Leprosy Recurre
