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培美曲塞治疗ECOG评分≥1晚期肺腺癌28例临床观察

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摘要 目的观察培美曲塞治疗晚期非小细胞肺癌(NSCLC)(肺腺癌)的近期疗效及毒副作用。方法选择ECOG评分≥1的28例肺腺癌病人应用培美曲塞治疗,每3周为1个周期重复。每2个周期评估疗效,最多4~6个周期。观察近期疗效和不良反应,进行随访。结果28例患者中CR0例(0%),PR5例(17.9%).SD7例(25.0%),PD16例(57.1%)。总有效率(CR+PR)为17.8%。疾病控制率(CR+PR+SD)为42.9%。主要的毒副反应骨髓抑制、恶心、呕吐和腹泻以及白细胞下降导致的发热等,但患者多为Ⅰ、Ⅱ度反应。耐受性良好。结论培美曲塞治疗功能状态评分差的晚期肺腺癌患者的疗效较好,不良反应较轻。患者的耐受性好。
出处 《海峡药学》 2011年第10期149-150,共2页 Strait Pharmaceutical Journal
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