摘要
目的:研究乌司他丁对重症急性胰腺炎(SAP)患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和高敏C-反应蛋白(hs-CRP)的影响。方法:80例SAP患者随机分成对照组和治疗组,每组40例。对照组给予西医常规治疗,治疗组在西医常规治疗的基础上加用乌司他丁,治疗10 d。观察治疗前后临床疗效,并分别在患者入院24 h内以及治疗7 d后采静脉血检测血清TNF-α、IL-6和hs-CRP的水平。结果:治疗后,治疗组临床疗效较对照组高(P<0.05);治疗7 d后,两组患者血清TNF-α、IL-6和hs-CRP水平均较治疗前显著降低(P<0.01),但治疗组下降更明显(P<0.01)。结论:乌司他丁可降低SAP患者血清TNF-α、IL-6和hs-CRP水平,抑制炎性反应。
Objective To study the influence of ulinastatin on the serum TNF-α,IL-6 and hs-CRP in the patients with severe acute pancreatitis（SAP）.Method Eighty SAP patients were randomly divided into the control group and the treatment group with forty patients in each group.Both groups were given routine treatment,while the patients of the treatment group were given ulinastatin in addition,for 10 days.The clinical curative effect was assessed and the serum levels of TNF-α,IL-6 and hs-CRP were measured on the first and seventh day in both groups.Results Compared with the control group,the clinical curative effect of ulinastatin treatment increased（P0.05） after treatment.The serum levels of TNF-α,IL-6 and hs-CRP were significantly decreased in both groups after 7 days（P0.01）,while the declining of the serum levels of the three cytokines in the treatment group were more obvious than that in the control group（P0.01）.Conclusion Ulinastatin can treat SAP patients by reducing the serum levels of TNF-α,IL-6 and hs-CRP,inhibiting inflammatory reaction.
出处
《吉林医学》
CAS
2011年第31期6604-6605,共2页
Jilin Medical Journal
