摘要
非酒精性脂肪性肝病(NAFLD)是指与过量饮酒无关的临床综合征,主要病理改变包括肝细胞弥漫性脂肪变性和脂肪堆积。NAFLD动物模型表现出显著的肝脏微循环障碍,关于其形成机制,被广为接受的为"二次打击"学说。该学说认为肥胖、胰岛素抵抗等因素作为"第一次打击",导致肝脏中脂质堆积,形成单纯性脂肪肝,增加了"第二次打击"造成的肝脏损伤的易感性,这些因素包括炎症、枯否细胞功能障碍、氧化应激、线粒体障碍、脂肪因子调节紊乱等,导致非酒精性脂肪性肝炎甚至纤维化等更严重疾病的发生。
Non-alcoholic fatty liver disease（NAFLD）,a clinical syndrome unrelated to excessive alcohol intake,is char-acterized by diffuse fatty degeneration of liver cells and fat accumulation.Animal models of NAFLD exhibit obvious hepatic mi-crocirculation dysfunction.The widely accepted pathogenesis of NAFLD was based on ′2-hit hypothesis′.Obesity and insulin re-sistance as the ′first-hit′ lead to hepatic triglyceride accumulation or steatosis,increase susceptibility of the liver to injury me-diated by ′second-hit′,such as inflammation,Kupffer cell dysfunction,mitochondrial dysfunction,oxidative stress,and adipokines adjustment disorders,which in turn lead to steatohepatitis,even fibrosis.
出处
《国际药学研究杂志》
CAS
2011年第5期341-344,共4页
Journal of International Pharmaceutical Research
基金
科技部"重大新药创制"科技重大专项"十一五"计划(2009ZX09103-432
2009ZX09303-003)
关键词
非酒精性脂肪性肝病
微循环
流行病学
实验动物模型
发病机制
non-alcoholic fatty liver disease（NAFLD）
microcirculation
epidemiology
experimental animal mod-els
pathogenesis
