摘要
顺铂被广泛应用于肺癌的临床化疗，但耐药性的产生严重影响其疗效。顺铂耐药的机制尚不十分清楚。目前普遍认为P-糖蛋白（P-gp）的表达情况与顺铂耐药性相关。抑制p-gP的表达可克服顺铂耐药性，提高治疗疗效。
Cisplatin is widely used in lung cancer chemotherapy, but drug resistance seriously affects its efficacy. The mechanism of cisplatin resistance is not yet clear. Now it is widely recognized that P-glycoprotein （P-glycoprotein, P-gp） expression is associated with cisplatin resistance. Inhibition of P-gp expression can overcome cisplatin resistance and improve the treatment efficacy.
出处
《肿瘤研究与临床》
CAS
2011年第8期565-567,共3页
Cancer Research and Clinic
关键词
肺肿瘤
糖蛋白类
顺铂
抗药性
肿瘤
Lung neoplasms
Glycoproteins
Cisplatin
Drug resistance, neoplasms
