摘要
目的:探究术中动脉灌注化疗(intraoperation artery infusion chemotherapy,IAIC)联合腹腔灌注化疗对胃癌患者预后的影响。方法:筛选2006年3月-2007年9月就诊于我科的91例年龄≤75岁的胃癌患者随机分为实验组(47例)和对照组(44例)。实验组术中经瘤体的主要供血动脉及腹腔共给予5-氟尿嘧啶1000mg及丝裂霉素10mg,对照组给予等体积生理盐水后单纯行常规手术切除,术后两组患者均给予FAP方案(5-氟尿嘧啶600mg/m2d1、丝裂霉素30mg/m2 d1、顺铂20mg/m2 d1-5)化疗,总疗程4-6次。结果:实验组1年、2年、3年生存率分别为89.36%、76.09%、58.70%。3年局部复发率、腹腔转移率、肝脏转移率分别为26.09%、15.22%、21.74%。对照组1年、2年、3年生存率分别为90.91%、60.47%、32.56%。3年局部复发率、腹腔转移率、肝脏转移率分别为46.51%、25.58%、18.60%。中位生存时间实验组为36个月,而对照组为27个月。两组间3年腹腔转移率差异较大,但无统计学意义(P>0.05)。3年生存率及局部复发率的差异有统计学意义(P<0.05)。结论:术中动脉灌注联合腹腔灌注5-氟尿嘧啶及丝裂霉素,可有效提高患者的远期生存率,同时降低局部复发率。并对腹腔转移率的降低可能有意义。
Objective：To test whether intraoperation artery infusion chemotherapy（IAIC）combined with intraoperation intraperitoneal chemotherapy（IIC） can improve survival in respectable gastric cancer.Methods：Total of 91 patients aged ≤75 years,who had histologically proven gastric cancer,and randomly assigned them by minimization to receive either： Intraoperation artery infusion chemotherapy（5-Fluorouracil 750mg and Mitomycin 8mg） combined with intraoperation intraperitoneal chemotherapy（5-Fluorouracil 250mg and Mitomycin 2mg）（n=47） and operation or only operation（n=44）.And all the enrolled patients had a adjuvant radiation with the chemotherapy of FAP regimen（5-Fluorouracil 600 mg/m2 d1 and Mitomycin 30mg/m2d1 Cisplatin 20 mg/m2d1-5） after operation.Results：Patients receiving IAIC and IIC,their 1,2 and 3-year survival rates were 89.36%,76.09%,58.70%,while patients receiving only operation were 90.91%,60.47%,32.56%.The 3-year local recurrence rate,3-year abdomen metastasis rate and 3-year liver metastasis rate in patients receiving IAIC and IIC were 26.09%,15.22%,21.74%,while 46.51%,25.58%,18.60% in the other group.And the difference in 3-year survival rate and 3-year local recurrence rate between the two groups had statistical differences.Conclusion：Intraoperation artery infusion chemotherapy（IAIC）combined with intraoperation intraperitoneal chemotherapy using 5-Fluorouracil and Mitomycin can induce the local recurrence rate and improve the long-term survival.
出处
《现代肿瘤医学》
CAS
2011年第8期1617-1620,共4页
Journal of Modern Oncology
关键词
动脉灌注化疗(IAIC)
腹腔灌注化疗
胃癌
5-氟尿嘧啶
丝裂霉素
intraoperation artery infusion chemotherapy（IAIC）
intraperitoneal chemotherapy
gastric cancer
5-Fluorouracil
mitomycin
